MULTIPURPOSE ARTHRITIS CENTER

多功能关节炎中心

• 批准号: 3108249
• 负责人: JOHN B WINFIELD
• 金额: $ 83.95万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3108249
• 关键词: arthritis; arthritis education; rheumatoid arthritis

The Multipurpose Arthritis Center at the University of North Carolina in Chapel Hill consists of a Biomedical Research Component, a Non-Biomedical Research Component, an Immunology Core, a Numerical Sciences Core, and an Administrative Core. Areas of special emphasis in the Biomedical Component include: molecular and functional studies of autoantibodies in SLE and related diseases; basic mechanisms in murine models of autoimmunity; the genetics and idiotypy of rheumatoid factor and other autoantibodies; the molecular biology of the MHC; characterization of cellular activation antigens; the structure and cell biology of complement receptors; B cell differentiation; complement and disease; autoimmunity to collagen: bacterial cell wall constituents as triggers and activators of erosive synovitis; and oncogenes and autoimmunity. Five Developmental and Feasibility projects are proposed. Four are molecular biology/genetic investigations of basic questions in autoimmunity or inflammation. The fifth will test the feasibility of developing a novel and potentially useful new model of reactive arthritis in monkeys. Building upon a strong base in education and community activities, the Non-Biomedical Research Component proposes six projects. Two projects focus on the education of medical students in rheumatol- ogy. Two projects are behavioral theory-based investigations of patients with arthritis, continuing a tradition of social and behavioral research in this Component. One project examines the clinical encounter between physicians and patients, with the goal of improving patient-doctor communication. The final project concerns arthritis work disability in a rural southern community, and reflects a major focus on community-based epidemiological research. Already-funded laboratory research will be supported by an Immunology Core, which will develop and maintain immunological and scientific databases, produce monoclonal antibodies, support a HPLC facility, provide flow cytometry, and maintain a pathogen- free inbred mouse colony. A Numerical Sciences Core will support research efforts in the Non-Biomedical Component with respect to research design and methodology, data collection, project participant registry, data processing, database management, and data analysis. The Administrative Core will provide overall coordination and support of MAC activities, perform internal review, and assure optimum liaison within the University and in the community.

北方大学多功能关节炎中心 位于查佩尔山的卡罗莱纳由一个生物医学研究所组成， 组件，非生物医学研究组件，免疫学核心， 一个数字科学核心，和一个行政核心。 领域 生物医学部分的特别重点包括：分子 系统性红斑狼疮及其相关疾病自身抗体的研究 疾病;小鼠自身免疫模型的基本机制; 遗传学和类风湿因子和其他的独特性 自身抗体; MHC分子生物学;特性 细胞活化抗原的结构和细胞生物学 补体受体; B细胞分化;补体和 疾病;胶原蛋白自身免疫;细菌细胞壁 作为糜烂性滑膜炎的触发剂和激活剂的成分;以及 癌基因和自身免疫。 五、发展性和可行性 提出了项目。 四是分子生物学/遗传学 研究自身免疫或炎症的基本问题。 第五个将测试开发一种新的， 潜在有用的新模型反应性关节炎的猴子。 在教育和社群活动的坚实基础上， 非生物医学研究部分提出了六个项目。 两 项目重点是对医学生进行风湿性关节炎教育， 奥吉。 两个项目是基于行为理论的调查， 关节炎患者，继续社会和 行为研究在这一部分。 一个项目研究了 医生和病人之间的临床接触，目标是 改善医患沟通的方法。 最终项目 关注南部农村社区的关节炎工作残疾， 并反映了对以社区为基础的流行病学的主要关注 research. 已经资助的实验室研究将得到以下方面的支持： 免疫学核心，将开发和维持免疫学 和科学数据库，生产单克隆抗体，支持 一个高效液相色谱仪，提供流式细胞仪，并保持病原体- 自由近交系小鼠群体。 数字科学核心将支持 非生物医学部分的研究工作， 研究设计和方法，数据收集，项目 参与者登记、数据处理、数据库管理，以及 数据分析 行政核心将提供全面的 协调和支持MAC活动，执行内部 审查，并确保在大学和在最佳联络 社区