IGF 1 WITH GH, INSULIN, AND AMINO ACIDS IN REGULATION OF HUMAN MUSCLE METABOLISM

这项研究考察了胰岛素样生长因子-1的相互作用 (IGF-1)与生长激素、氨基酸和胰岛素在人体骨骼上的作用 肌肉蛋白质代谢。基线测量后，IGF-1将 动脉内输注，全身添加生长激素或氨基酸。在……里面 在另一项研究中，胰岛素将与IGF-1共同注射。重复 测量将在输液3小时和6小时后进行。这些 研究已经证明了血管和代谢的影响 健康对照组动脉内注入胰岛素样生长因子-1。IGF-1 显著刺激前臂血流，骨骼肌葡萄糖摄取， 和蛋白质合成代谢。最近，我们注意到， IGF-1是针对性别的。

This research examines the interactions of insulin-like growth factor-1 (IGF-1) with growth hormone, amino acids, and insulin on human skeletal muscle protein metabolism. After baseline measurements, IGF-1 will be infused intraarterially and GH or amino acids added systemically. In a separate study, insulin will be co-infused with IGF-1. Repeat measurements will be made after 3 and 6 hours of infusions. These studies have demonstrated both the vascular and metabolic effects of IGF-1 infused intra-arterially in healthy control subjects. IGF-1 markedly stimulates forearm blood flow, skeletal muscle glucose uptake, and protein anabolism. Most recently, we have noted that the effect of IGF-1 is gender specific.