PK OF LIQUID IBUPROFEN IN INFANTS, TODDLERS AND PRESCHOOLERS W/ CYSTIC FIBROSIS

口服可减轻囊性纤维化的炎性气道损伤 布洛芬治疗的条件是呼吸道损伤处于早期阶段。最多的 因此，提供这种疗法的重要时间是在 儿童慢性支气管炎早期呼吸道炎症和损伤 谁不能服用布洛芬片剂；需要液体制剂来 给他们治病。液体布洛芬的药代动力学尚不清楚。 患有CF&lt；6岁的儿童，它可能在婴儿、蹒跚学步的孩子中有所不同 和学龄前儿童，来自年龄较大的儿童和患有CF的成年人。这个 液体布洛芬的吸收也可能与片剂不同 布洛芬。本研究将描述液体的药代动力学。 布洛芬用于婴幼儿和学龄前儿童。这是意料之中的 这种液体布洛芬吸收更快、更均匀、更容易 完全比片剂配方好。因此，血浆浓度 将以更快的速度上升，更早达到峰值，然后以更可预测的方式衰退 时尚。

The inflammatory airway injury in Cystic Fibrosis can be lessened by oral ibuprofen therapy provided airway injury is in its early stages. The most important time to offer this therapy is, therefore, before or during the early phases of airway inflammation and injury in young children with CF who cannot take tablets of ibuprofen; liquid formulations are needed to treat them. The pharmacokinetics of liquid ibuprofen is not known in children with CF<6 years of age, and it may differ in infants, toddlers and preschool children from older children and adults with CF. The absorption of liquid ibuprofen may also differ from tablet formulations of ibuprofen. This study will describe the pharmacokinetics of liquid ibuprofen in infants, toddlers and preschool children. It is anticipated that liquid ibuprofen is absorbed faster, more uniformly and more completely than tablet formulation. As a result, plasma concentrations will rise faster, reach a peak sooner and then decay in a more predictable fashion.