PHASE III STUDY OF HIGH DOSE TAMOXIFEN IN METASTATIC MELANOMA

该补助金的目的是探索可能的机制， 三苯氧胺与顺铂在恶性黑色素瘤中相互作用 细胞 该补助金涉及进行第一阶段和第二阶段的临床 在转移性黑色素瘤患者中进行的临床试验， 他莫昔芬和顺铂之间协同作用的重要性。 相关 计划进行研究以确定临床反应的体内预测因子。 此外，计划进行体内研究，以确定潜在的 三苯氧胺与顺铂的协同作用机制。

The purpose of this grant is to explore the possible mechanisms of interaction between tamoxifen and cisplatin in human malignant melanoma cells. This grant involves the conduct of a phase I and phase II clinical trial in patients with metastatic melanoma to investigate the clinical importance of synergy between tamoxifen and cisplatin. Correlative studies are planned to determine in vivo predicators of clinicalresponse. Additionally, in vivo studies are planned to determine the underlying mechanism of synergy between tamoxifen and cisplatin.