RAMIFICATIONS OF HLA RESTRICTION TO VACCINE PRODUCTION

已有研究表明，人类白细胞抗原的限制可能起到重要的作用 通过疫苗接种在免疫发展中的作用。 目前的努力主要集中在人类白细胞抗原I类等位基因和多肽疫苗上， 并对15个民族的积极反应水平进行了预测 基于群体遗传模型和已知等位基因的群体 HLAI类基因座的单倍型频率。覆盖范围的估计 基于这些频率获得了概率，并且 达到这种覆盖范围所需的等位基因的可能数量一直是 根据个人人口、种族分组和所有 十五个民族。

It has been suggested that HLA restriction may play a significant role in the development of immunity through vaccine administration. Current efforts focus on the HLA class I alleles and peptide vaccines, and on the prediction of levels of favorable response in 15 ethnic groups, based upon population genetic models and known allele and haplotype frequencies for class I HLA loci. Estimates of coverage probabilities have been obtained based upon these frequencies, and the probable number of alleles needed to achieve such coverage has been obtained based upon individual populations, racial groupings, and all fifteen ethnic groups.