RENOVATION OF THE ULLMANN ANIMAL UNIT

在这份订正提交的文件中，要求提供相应的资金来翻新 阿尔伯特·爱因斯坦医学院的乌尔曼动物部，主修 小灵通投资超过4400万美元的生物医学研究机构 资金问题。乌尔曼动物单位面积为16,400平方英尺，包括 乌尔曼大楼的10层和11层，大约一半的房子 AECOM的研究动物，支持60多名研究人员和 学院的大部分主要研究项目。目标是(1) 将大部分未使用的犬舍改建为额外的栅栏啮齿动物空间 更灵活的空间，(2)改善对气流和甲石的控制- 在房间和走廊传播鼠类病原体，(3)改进笼子 消毒，(4)去除笼子清洗产生的热量和湿度， (5)更好地排出麻醉剂废气；(6)控制温度 对于非洲爪蛙，(7)移除动物房间的窗户，以及(8) 增加无病原体小鼠的住房。这些目标将通过以下方式实现 由四部分组成的翻修计划。在A部分，六个大房间将被改造成 创建两个屏障啮齿动物套房和两个多物种房间。障碍 啮齿动物套房将被用来重新派生和补充Ullman大楼的库存 没有病原体的啮齿动物。多品种的房间将灵活地容纳 少量的狗、猪或羊。在B部分，笼子清洗将是 扩展到存储肮脏的笼子，过时的隧道和机架清洗机将 将被更换，房间排气将升级。一个新的通风柜将会是 安装以排出大量使用的程序中产生的麻醉剂废气 房间。在C部分，室内补充冷却和新的笼子将 购买以允许非洲爪蛙的最佳栖息地和自然繁殖 通过提供低于72华氏度的温度，在D部分，31个窗户中有120个 两层楼的动物室将被取消，以允许光周期 控制和提高能源效率。这一套4个相关 翻修将允许急需的无病原体住房的扩建 啮齿动物，包括越来越多的免疫缺陷、转基因和 乌尔曼和夏宁大楼中的敲除老鼠。这些翻修工程 是迫切需要的，并将确保符合美国农业部动物保护标准 《福利法》和国土安全部有关房间温度的政策，控制 照明和通风，动物饲养员的工作条件。这个 翻新还将有助于我们保持AAALAC的认证。

In this revised submission, matching funds are requested to renovate the Ullmann Animal Unit of the Albert Einstein College of Medicine, a major biomedical research institution with more than 44 million dollars in PHS funding. The Ullmann Animal Unit of 16,400 net square feet includes the 10th and 11th floors of the Ullmann building and house approximately half of AECOM's research animals, supporting more than 60 investigators and most major research programs of the college. The objective are (1) to convert largely unused dog rooms to additional barrier rodent space and more flexible space, (2) to improve the control of airflow and formite- borne rodent pathogens in rooms and hallways, (3) to improve cage sanitization, (4) to remove heat and humidity generated by cage washing, (5) to better vent exhaust anesthetic gasses, (6) to control temperature for Xenopus frogs, (7) to remove windows from animal rooms, and (8) to increase housing for pathogen-free mice. These objectives will be met by a 4-part renovation plan. In Part A, six large rooms will be renovated to create two barrier rodent suites and two multi-species rooms. The barrier rodent suites will be used to re-derive and re-stock the Ullman Building with pathogen-free rodents. The multi-species rooms will flexibly house small numbers of dogs, pigs, or sheep. In Part B, the cage-wash will be expanded to store dirty cages, the antiquated tunnel and rack washers will be replaced and the room exhaust will be upgraded. A new fume hood will be installed to vent waste anesthetic gasses from a heavily-used procedure room. In Part C, in-room supplemental cooling and new caging will be purchased to permit optimal housing and natural breeding of Xenopus frogs by providing temperatures under 72 degrees F. In Part D, 120 windows in 31 animals rooms on two floors will be eliminated to permit photoperiod control and to increase energy efficiency. This set of 4 related renovations will permit much-needed expansion of pathogen-free housing for rodents, including increasing numbers of immunodeficient, transgenic and knock-out mice in both the Ullman and Chanin buildings. These renovations are urgently needed and will assure compliance with the USDA Animal Welfare Act and DHHS policies related to room temperatures, controlling lighting and ventilation, working conditions for animal caretakers. The renovations will also assist us in maintaining our AAALAC accreditation.