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ROLE OF MARTRLLC METALLOPROTEINASES IN DEVELOPMENT OF DIABETIC NEPHROPATHY

ROLE OF MARTRLLC METALLOPROTEINASES IN DEVELOPMENT OF DIABETIC NEPHROPATHY
MARTRLLC 金属蛋白酶在糖尿病肾病发展中的作用
批准号：
6283018
负责人：
LEONARD ARBEIT
金额：
$2.44万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-06-04 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6283018
关键词：
albuminuria basement membrane clinical research collagenase diabetes mellitus therapy diabetic nephropathy disease /disorder etiology glomerulosclerosis human subject human therapy evaluation insulin dependent diabetes mellitus kidney disorder chemotherapy pathologic process periodontium disorder proteinuria renal glomerulus tissue inhibitor of metalloproteinases

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中文摘要
翻译
假设：人类糖尿病肾病是由过度- 明胶酶的产生导致肾小球基底损伤 膜其次是肾小球硬化造成的异常伤口 治愈 具体目标： 1.人类I型糖尿病患者的肾脏明胶酶是否增加？ 2.肾明胶酶的增加是否与 出现微量白蛋白尿吗 3.微量白蛋白尿患者明胶酶抑制是否导致 减少白蛋白渗漏 4.明胶酶抑制剂对显性糖尿病患者的作用 肾病导致蛋白尿减少？ 5.抑制I型糖尿病患者的明胶酶是否会导致 糖尿病肾病的进展速度？ 6.抗明胶酶治疗是否也能减轻牙周炎的严重程度 这些糖尿病患者的疾病？
英文摘要
HYPOTHESIS: That human diabetic nephropathy is caused by an over- production of gelatinases resulting in damage to the glomerular basement membrane followed by glomerulosclerosis caused by the abnormal wound healing. SPECIFIC AIMS: 1. Are renal gelatinases increased in human Type I diabetes mellitus? 2. Is there a correlation with increase in renal gelatinases and the development of microalbuminuria? 3. Does inhibition of gelatinases in patients with microalbuminuria result in decreased albumin leak? 4. Does inhibition of gelatinases in patients with overt Diabetic nephropathy result in decreased proteinuria? 5. Does inhibition of gelatinases in Type I DM result in a decrease in the rate of progression of diabetic nephropathy? 6. Does anti-gelatinase therapy also reduce the severity of periodontal disease in these diabetic patients?
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ROLE OF MARTRLLC METALLOPROTEINASES IN DEVELOPMENT OF DIABETIC NEPHROPATHY
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