NUTRITION AND OBESITY--PHYSIOLOGIC MECHANISMS

识别和描述与肥胖有关的因素是至关重要的， 因此预防或扭转营养相关疾病的干预措施 肥胖可能会产生负面的健康后遗症。要做到这一点 需要更好地理解瘦身和肥胖在 决定人类食物摄入量的机制。本研究将 指示肥胖个体是否可以对内部生理反应 与食物中的能量含量有关的提示。音量的影响 一天内对食物和营养摄入量的控制将 准确地描述和测量，以确定是否苗条和肥胖 受试者可以补偿能量操纵，如果 口服或胃内(IG)预负荷对后续食物的影响不同 选择还是录取。这项研究将检验以下假设：a)两者 音量和能量信号必须存在，才能使IG有效 在减少随后的能量摄入方面。这将由以下因素决定 比较能源监管对不同能源现状的反应 B)肥胖者对以下情况的反应较差 机械和营养对胃的刺激比瘦身更好 个人。这将通过比较能源监管机构来确定 不同容量和能量的口服和免疫球蛋白预负荷后的反应 瘦人和肥胖者的密度。

It is critical to identify and characterize factors involved in obesity, so that interventions to prevent or reverse the nutrition-related negative health sequelae of obestity can be developed. To do so requires a better understanding of lean-obese differences in the mechanisms that determine human food intake. The present study will indicate whether obese individuals can respond to internal physiological cues related to the energy content of foods. The effects of volume manipulations on food and nutrient intake over a one day period will be accurately characterized and measured to determine if lean and obese subjects can compensate for energy manipulations and if volume of the oral or intragastric (IG) preloads differentially affect subsequest food choice or intake. The study will test the following hypotheses:a) Both volume and energy cues will have to be present for IG to be effective in reducing subsequent energy intake. This will be determined by comparing the energy regulatory responses to various energy-present pre- loads and no pre-loads.b) Obese individuals will be less responsive to mechanical and nutrient stimulation of the stomach than lean individuals. This will be determined by comparing energy regulatory responses after oral and IG preloads of different volumes and energy densities in lean and obese individuals.