ROLE OF CISAPRIDE IN TREATMENT OF INFANTILE COLIC

目前的建议是一个随机，安慰剂对照，双盲 交叉试验，以确定西沙必利，胃肠道 促动力，用于治疗婴儿绞痛。 研究期间 期间，父母不断哭泣的时间日志。 初步统计结果 分析未能显示西沙必利（0.87 +/- 1.49小时[平均ISD]和安慰剂（1.36 +/- 1.33小时）或父母 主观评分 为了显示有效性， 需要提示最低药物效力。 研究期间，18 招募受试者并终止研究。

The current proposal is a randomized, placebo-controlled, double-blinded crossover trial to determine the efficacy of cisapride, a gastrointestinal prokinetic, for the treatment of infantile colic. During the study period, parents keep crying time logs. Results of initial statistical analysis failed to show significant differences between cisapride (0.87 +/- 1.49 hours [mean ISD] and placebo (1.36 +/- 1.33 hours) or parental subjective rating. To show efficacy an extremely large sample size would be required suggesting minimal drug efficacy. During this study period 18 subjects were enrolled and the study terminated.