FATTY ACIDS AND TUMOR CHARACTERISTICS IN BREAST CANCER

描述：越来越多的证据支持参与特定的 个别脂肪酸在乳腺癌发生中的作用 多不饱和脂肪 ω-6（ω 6）家族的酸，特别是亚油酸，刺激 许多细胞培养和动物模型中的肿瘤增殖，以及w3脂肪 酸可以抑制增殖。 很少有研究在女性中解决这个问题， 而且大多数都受到所采取措施的限制。 拟定研究 将汇集两项大型乳腺癌研究， 从美国和欧洲妇女的脂肪酸摄入量来研究 脂肪酸对肿瘤发生和复发的影响。 脂肪酸组成 诊断时获得的臀脂肪标本将提供以下生物标志物： 具体脂肪摄入量。 其中一项研究的分析表明， 酸的摄入量和w3与w 6脂肪的比例增加对 欧洲女人 这项汇集了1400名女性的研究将提高研究的效力。 分析生物活性脂肪酸对乳腺癌的影响 使用摄入量范围广泛的人群发生。 另夕h 598例初诊6-10年乳腺癌病例 早些时候，将跟进，以确定是否脂肪酸商店 影响乳腺癌的复发。 也有计划检查 遗传不稳定性的修饰效应（如通过p53和 HER-2/neu表达），与雌激素受体状态的关系 生物活性脂肪酸（反映在脂肪组织中）和 乳腺癌的发病率 他们还将检查是否增殖 恶性细胞的能力（Ki-67表达，如通过肿瘤 标记物MIB-1）受生物活性脂肪酸的组织水平影响。 acids. 使用分层分析，研究人员将确定是否 这仅是雌激素依赖性肿瘤的情况。 本项多中心 一项研究提供了一个妇女的混合样本，其暴露范围超过 这可以从大多数研究中获得。 基于脂肪组织的直接测量 脂肪酸储存可从比以前更多的个体获得 在任何一项研究中。 这将是第一个使用 既往脂肪酸摄入的生物标志物，有足够的把握度评估 富含w3脂肪酸的饮食对预防乳腺癌的潜在作用 癌症复发 它还具有独特的地位，可以解决 特定的肿瘤特征和脂肪酸作为决定因素 乳腺癌

DESCRIPTION: Growing evidence supports the involvement of specific individual fatty acids in mammary carcinogenesis. Polyunsaturated fatty acids of the omega-6 (w6) family, particularly linoleic acid, stimulate tumor proliferation in many cell culture and animal models, and w3 fatty acids can suppress proliferation. Few studies have addressed this in women, and most of those are limited by the measures employed. The proposed study will pool two large breast cancer studies with adipose tissue markers of fatty acid intakes from American and European women to study the effects of fatty acids on tumor occurrence and recurrence. Fatty acid composition of gluteal fat specimens obtained at diagnosis will provide a biomarker of specific fat intake. Analyses from one of the studies suggest that w3 fatty acid intakes and increasing ratios of w3 to w6 fat are protective in European women. The pooled study, with 1400 women, will have enhanced power to analyze effects of the biologically active fatty acids on breast cancer occurrence using populations with wide ranges of intake. Additionally, the 598 cases initially diagnosed with incident breast cancer 6-10 years earlier, will be followed-up to determine whether fatty acid stores influence the recurrence of breast cancer. There are also plans to examine the modifying effects of genetic instability (as measured by p53 and HER-2/neu expression), and estrogen receptor status on the relationship between biologically active fatty acids (as reflected in adipose tissue) and breast cancer in these women. They will also examine whether proliferative capacity of malignant cells (Ki-67 expression as measured by the tumor marker MIB-1) is affected by tissue levels of biologically active fatty acids. Using stratified analyses, the investigators will determine whether this is the case only for estrogen dependent tumors. This multi-center study provides a pooled sample of women with a range of exposures wider than that obtainable from most studies. Direct adipose tissue-based measures of fatty acid stores are available from more individuals than previously assembled in any single study. This will be the first study using biomarkers of prior fatty acid intake with adequate power to assess the potential role of diets rich in w3 fatty acids on the prevention of breast cancer recurrence. It is also uniquely positioned to address the importance of specific tumor characteristics and fatty acids in concert as determinants of breast cancer.