FASEB CONFERENCE-- CILIATE MOLECULAR BIOLOGY

描述（由申请人提供）：要求部分支持 第八届国际纤毛虫分子生物学会议。“这次会议 将在萨克顿河的佛蒙特学院举行FASEB会议， 佛蒙特州，2001年7月28日至8月2日。 这次会议将汇集 研究人员采用分子方法来研究各种 以纤毛虫原生动物为模型系统的生物学问题。 伟大 纤毛虫的价值源于它们不同寻常的遗传组织和广泛的， 基因组的发育程序重组。 这些特点 对一系列基本的染色体 过程，包括发现自我剪接RNA，端粒和 端粒酶和组蛋白乙酰转移酶引起的染色质重塑。 最近 进展，如通过同源重组进行靶向基因置换， 反义核糖体已被用于研究一系列广泛的问题， 细胞和分子生物学，从端粒和端粒酶， 调节蛋白质分泌，微管蛋白修饰 组装件. 研究的步伐加快，由于发展和 推广新的实验方法。 由于这个原因和其他原因， 纤毛虫分子生物学会议填补了一个关键的利基，否则 在其他科学会议上缺乏。 1999年的会议包括一个研讨会 用于评估实际问题和四膜虫基因组的合理性 测序项目。 人类生物学和医学的一个大范围的领域 会受到这个项目的有利影响 随后的会议将发挥 重要的组织作用，并将促进努力产生 需要集体承诺来推动这一项目。 纤毛虫分子生物学会议将分为九个平台 会议和两个海报会议。 平台会议将涵盖前沿 研究课题包括染色质重塑、端粒和端粒酶、DNA 重排，DNA复制，信号转导，细胞骨架， 进化和基因组可塑性。 约170名国内外 科学家将出席会议。 本次会议的组织者是 Geoffrey Kapler博士（DNA复制，德克萨斯A&M），Jacek Gaertig博士（ 细胞骨架，格鲁吉亚大学（UG））和Laura Landweber博士（进化， Princeton University）.

DESCRIPTION (provided by applicant): Partial support is requested for the "Eighth International Meeting on Ciliate Molecular Biology." This meeting will be held as a FASEB Conference at the Vermont Academy in Saxtons River, Vermont, July 28 - August 2, 2001. The meeting will bring together researchers who employ molecular approaches for investigating diverse biological problems using ciliated protozoa as their model system. The great value of ciliates stems from their unusual genetic organization and extensive, developmentally-programmed reorganization of the genome. These features have provided remarkable insights into an array of fundamental chromosomal processes, including the discovery of self-splicing RNA, telomeres and telomerase, and chromatin remodeling by histone acetyltransferases. Recent advances, such as targeted gene replacement by homologous recombination and intisense ribosomes have been exploited to study a wide range of questions in cell and molecular biology, ranging from telomeres and telomerase, to regulated protein secretion, to tubulin modification during microtubule assembly. The pace of research has quickened due to the development and dissemination of new experimental methods. For this reason and others, the Ciliate Molecular Biology Meeting fills a critical niche that is otherwise lacking in other scientific meetings. The 1999 meeting included a workshop for assessing practical issues and justification for a Tetrahymena genome sequencing project. A large spectrum of areas in human biology and medicine could be favorably impacted by this project. Subsequent meetings will play an important organizational role and will facilitate efforts to generate the collective commitment needed to move this project forward. The Ciliate Molecular Biology meeting will be organized into nine platform sessions and two poster sessions. Platform sessions will cover leading edge research topics including chromatin remodeling, telomeres and telomerase, DNA rearrangement, DNA replication, signal transduction, the cytoskeleton, evolution, and genome plasticity. Approximately 170 foreign and domestic scientists will attend the meeting. The organizers for this conference are Dr. Geoffrey Kapler (DNA replication, Texas A&M), Dr. Jacek Gaertig (the cytoskeleton, University of Georgia (UG)) and Dr. Laura Landweber (evolution, Princeton University).