ROLES OF HOX GENES IN SKIN & HAIR FOLLICLE DEVELOPMENT

描述：(改编自申请人的摘要)-独特的表达方式 系统发育保守的同源异型盒(HOX)许多成员的模式 发育中和成人皮肤中的基因家族与这组 控制皮肤图案化和再生过程的基因。这个 首席调查员有初步数据表明转基因小鼠 Hoxc13(GC13小鼠)在出生前和出生后皮肤中的过表达 毛囊和表皮角质形成细胞过度增殖。这些老鼠 表现为脱发和类似鱼鳞病的进行性皮肤缺陷。这 动物模型将被用来定义其背后的分子机制 异常，通过研究Hoxc13及其邻近的Hoxc13的表达， 正常皮肤和正常皮肤组织中差异表达基因的筛选 Hoxc13突变小鼠皮肤Hox12基因敲除与显性的比较 功能获得小鼠，以及Hoxc13和Hoxc12的转录调控。

DESCRIPTION: (Adapted from applicant's abstract) - The distinct expression patterns of many members of the phylogenetically conserved homeobox ("HOX") gene family in both developing and adult skin implicate this group of controller genes in patterning and regenerative processes of the skin. The principal investigator has preliminary data that transgenic mice over-expressing Hoxc13 (GC13 mice) in pre- and postnatal skin exhibit hyperproliferation of follicular and epidermal keratinocytes. These mice exhibit alopecia and a progressive skin defect resembling ichthyosis. This animal model will be used to define the molecular mechanisms underlying these abnormalities, by studying expression of Hoxc13 and its neighbor Hoxc13, screening for differentially expressed mRNAs in skin of normal versus Hoxc13-mutant mouse skin, comparison of Hox12 knockout versus dominant gain-of-function mice, and transcriptional regulation of Hoxc13 and Hoxc12.