DOSE-RELATED NEUROBEHAVIORAL EFFECTS OF CHRONIC COCAINE USE

本研究的目的是评估可卡因滥用者的神经行为和神经心理表现。虽然可卡因使用是一个重大的公共卫生问题，但缺乏关于长期神经行为影响的科学数据。这项研究考察了慢性可卡因使用与神经行为表现之间的剂量相关关系。对30名戒断的慢性可卡因滥用者和21名年龄、教育程度和智力相匹配的非吸毒对照者进行了一系列神经心理测试。在控制了年龄、受教育程度和智力后，更多的可卡因使用（每周克数）与执行功能、视觉感觉、精神运动速度和手灵巧性测试的较大下降有关。这些结果表明，长期使用可卡因与认知功能的持续下降有关，这种下降在重度使用者中最为明显。了解慢性可卡因使用者的特定认知加工缺陷将有助于设计个性化的药物治疗方案。-脑/药物效应，可卡因，神经心理测试，治疗-人类受试者：访谈，问卷调查或仅限调查

The purpose of this project is to assess the neurobehavioral and neuropsychological performance of cocaine abusing individuals. Although cocaine use is a significant public health problem, there is a paucity of scientific data on long-term neurobehavioral effects. This study examined the dose-related association between chronic cocaine use and neurobehavioral performance. A battery of neuropsychological tests was administered to 30 abstinent chronic cocaine abusers and 21 non- drug- using control subjects matched for age, education, and intelligence. After controlling for age, education, and intellectual ability, greater use of cocaine (grams per week) was associated with larger decrements on tests measuring executive functioning, visuoperception, psychomotor speed, and manual dexterity. These results suggest that chronic cocaine use is associated with persistent decrements in cognitive function that are most pronounced in heavy users. Knowledge of specific cognitive processing deficits in chronic cocaine users would be useful for designing individually tailored drug treatment programs. - Brain/drug effects, Cocaine, Neuropsychological Tests, Treatment - Human Subjects: Interview, Questionaires, or Surveys Only