Electromechanical Endocardial Mapping for Assessment of Myocardial Viability

一种新的左心室（LV）测绘系统（Biosense公司）使用低强度磁场能量来确定传感器尖端导管电极在左心室内的位置。在前期实验和人体研究心肌缺血程度与电信号幅度相关性的基础上，我们假设这种一体化的左室机电标测系统可以根据心内膜机电信号的程度来区分健康心肌与缺血心肌或不动心肌。如果这一假设得到证实，在导管实验室中在线检测心肌活力和缺血的能力可能是可行的。本研究试图通过比较静息和药物刺激时的左室机电制图数据，以及冠状动脉疾病患者的MRI、PET、铊和回声成像研究，来区分缺血、不动和正常心肌。一旦这项技术作为左室内的引导工具得到完善，我们将开始研究使用这种输送系统进行激光血运重建术和血管生成载体的直接注射。-心肌活力，缺血，PET， MRI，心内膜机电测绘-人类受试者

A novel left ventricular (LV) mapping system (Biosense, Inc.) uses low- intensity magnetic field energy to determine the location of sensor- tipped catheter electrodes within the LV. On the basis of previous experimental and human studies correlating the extent of myocardial ischemia with the amplitude of electrical signals, we hypothesize that such an integrated LV electromechanical mapping system could be used to distinguish healthy from ischemic or immobile myocardium on the basis of the extent of electromechanical endocardial signals. If this hypothesis is confirmed, the ability to detect on-line myocardial viability and ischemia in the catheterization laboratory may be feasible.The present study attempts to distinguish between ischemic, immobile, and normal myocardium by comparing LV electromechanical mapping data at rest and during pharmacologic stimulation, with imaging studies using MRI, PET, thallium and echo in patients with coronary artery disease.Once this technique is perfected as a guidance tool within the LV, we will embark on studies using this delivery system for laser revascularization and direct injection of angiogenic vectors. - Myocardial viability, ischemia, PET, MRI, electromechanical endocardial mapping - Human Subjects