Investigation of the Feasibility of Blocking HIV Infection with Chemokines.

趋化因子曾被用作抗艾滋病感染的临床试验的潜在疗法，但失败了。然而，这些试验使用输液作为治疗，而不是刺激固有的趋化因子系统。在物理化学的基础上，输液疗法本应失败。这项研究的目的是确定艾滋病患者的淋巴中需要诱导的天然趋化因子的水平，以产生对艾滋病毒的治疗效果。从短孵化时间和相对较低的细胞浓度的实验室条件到淋巴结条件的外推可以通过已建立的MOA(附着的多重性)理论来完成。目前正在进行收集这一外推所需数据的实验，初步实验表明该科学方案是可行的。-艾滋病毒、趋化因子、艾滋病、数学建模

Chemokines have been used as a potential therapy in clinical trials against AIDS infection, but failed. The trials used infusion as a therapy, however, and not stimulation of inherent chemokine systems. On physicochemical grounds, infusion therapy should have been expected to fail. This study is aimed at determining the level of natural chemokines that will need to be induced in the lymph nodes of AIDS patients to produce a therapeutic effect against HIV. The extrapolation from laboratory conditions of short incubation times and relatively low cell concentrations to lymph node conditions can be accomplished by established MOA (multiplicity of attachment) theory. Experiments to collect the data necessary to this extrapolation are presently underway and pilot experiments indicate that the scientific programme is feasible. - HIV, Chemokines, AIDS, Mathematical Modeling