CLINICAL RADIATION PHYSICS SERVICE

该科继续为放射治疗提供专家实物和技术支助，包括所有辐射生产和辅助设备的例行校准、质量保证和一线维护。它包括特殊剂量研究、计算机辅助治疗计划、患者监测以及为发展临床需求量身定做的特殊设备的设计和开发。二极管现已在临床上用于验证患者的剂量，准确度为+/-3。放射外科系统已安装并投入使用。到目前为止，我们已经成功地治疗了25名立体定向放射外科患者，并计划利用可植入支架附着点从单一部分转移到多部分放射外科。与海军研究实验室合作评估半导体掺杂Vycor玻璃的临床实用价值的项目正在顺利进行。我们正在继续对剂量学特性进行表征，并使用这些数据来改进探测器的开发。临床试验预计将于1999年初冬开始。迷你多叶准直器已经投入使用，不久将开始临床使用。正在进行的项目是启用能够治疗更复杂的肿瘤体积的改进的立体定向治疗计划系统，以及开发调强放射治疗(IMRT)。序列驱动的调强放射治疗正在等待新的记录和验证系统的交付，该系统已经订购。在NCI建立调强放射治疗研究计划将包括开发无框架立体定向定位系统。

The section continues to provide expert physical and technological support for radiation treatment, consisting of routine calibration, quality assurance and first-line maintenance of all radiation producing and ancillary equipment. It includes special dosimetry studies, computer- assisted treatment planning, patient monitoring and the design and development of special equipment tailored to developing clinical needs. Diodes are now in routine clinical use for the verification of patient doses and exhibit an accuract of +/- 3. The radiosurgery system has been installed and commissioned. To this date, we have successfully treated 25 stereotactic radiosurgery patients and plan to migrate from single fraction to multi fraction radiosurgery utilizing implantable frame attachment points. The project in collaboration with the Naval Research Laboratory to evaluate the clinical utility of semiconductor doped Vycor glass is well under way. We are continuing the characterization of the dosimetric properties and using these data to refine detector development. Clinical trials are expected to start by early Winter, 1999. The mini multileaf collimator has been commissioned and clinical use will commence shortly. Ongoing projects are the commisioning of a refined stereotactic treatment planning system capable of treating more complex tumor volumes and the development of intensity modulated radiation therapy (IMRT). Sequence driven IMRT is awaiting the delivery of a new Record-and Verify system, which has been ordered. The establishment of an IMRT research program at NCI will include the development of a frameless stereotactic localization system.