NOVEL APPROACH TO TIPS: STENT POLYMER PAVING COMPOSITES

描述(逐字摘自申请人摘要)：在管理中 经颈静脉肝内静脉曲张出血的肝硬变患者 门体分流(TIPS)在门静脉减压中起着重要作用。 并防止频繁再出血的危险。这一进程的进展 创伤性更小的非手术门静脉减压术成为可能。 通过对血管支架的临床介绍。起初，气球 可膨胀支架，如Palmaz支架或Tantalum Strecker支架 然而，在TIPS程序中，许多人最终转向了自我扩展 支架，如Wallstent、Nitinol Stecker支架、Memtherm支架或 GianturcolRosch支架因其更容易而变得更受欢迎 部署和各种规模可用。然而，有内在的 所有自膨式支架在弹性、长度、 直径、纵向弹性环强度、网状轮廓和输送 系统，这些因素会影响它们的性能。 尽管TIPS迄今在临床上取得了成功，但仍存在几个主要挑战。 由于以下原因导致的肠道关闭，可能会导致TIPS的早期故障 氧化铝中的生物泄漏！血栓形成、支架扩张不完全或支架 迁移。更常见的是，TIPS的通畅性在 由于组织内生长，放置后几个月。这些和其他限制 必须解决当前TIPS实践的问题，以确保持久的通畅性和 TIPS的有效率。这是本一期工程的具体目标 通过引入组合来解决这些限制中的一些 镍钛合金支架与粘附性聚合物腔内层结合。伯克利 应用科学与工程公司(BASE)在 将镍醇用于各种工业和医疗应用。这个 合作研究人员斯莱宾博士是该技术的发明者和开发者 聚合物腔内铺装。在阶段L期间，优势的组合将是 利用，包括碱的数学模拟和聚合物的专业知识 斯莱宾实验室的。将制作支架原型样品，并进行有限的 将进行动物研究，以证明TIPS目前的局限性 程序可以改进。 建议的商业应用： 不可用

DESCRIPTION (Verbatim From Applicant's Abstract): In the management of cirrhotic patients with variceal bleeding, transjugular intra-hepatic portosystemic shunt (TIPS) plays an important role in decompressing the portal system and preventing the danger of frequent rebleeding. The advance of this less invasive, non-surgical approach of portal decompression was made possible through the clinical introduction of vascular stents. At first, balloon expandable stents, such as Palmaz stents or Tantalum Strecker stents were employed in TIPS procedure, however, in time, many switched to self-expanding stents such as Wallstent, Nitinol Stecker stents, Memotherm stents, or GianturcolRosch stents, which became more popular due to their easier deployment and variety of size available. However, there are intrinsic differences among all self-expanding stents regarding elasticity, length, diameter, longitudinal flexibility hoop strength, mesh profile, and delivery system, which influence their performance. Despite the clinical success of TIPS to date, several major challenges remain. Early malfunction of TIPS may occur due to tract closure resulting from bioleakage intralumina! thrombosis, incomplete stent expansion, or stent migration. More commonly, TIPS patency is compromised progressively in the months following placement due to tissue in-growth. These and other limitations of current TIPS practice must be resolved to ensure durable patency and efficacy rates for TIPS. It is the specific objective of this Phase I project to resolve some of these limitations through introduction of a composite nitinol stent combined with in adherent polymeric endoluminal layer. Berkeley Applied Science & Engineering, Inc. (BASE) has developed a unique expertise in using nitinol for various industrial and medical applications. The co-investigator, Dr. Slepian, was the original inventor and developer of polymeric endoluminal paving. During Phase l.a combination of strengths will be utilized, including mathematical simulation of BASE and the polymeric expertise of the Slepian lab. Prototype stent samples will be fabricated and a limited animal study will be done to demonstrate how present limitations of TIPS procedure can be improved. PROPOSED COMMERCIAL APPLICATION: Not Available