A CAD SYSTEM FOR NICKLE-TITANIUM MEDICAL DEVICE

镍钛医疗器械CAD系统

• 批准号: 6390064
• 负责人: M PANAHANDEH
• 金额: $ 73.89万
• 依托单位: BERKELEY APPLIED SCIENCE AND ENGINEERING
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6390064
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; blood vessel prosthesis; computer human interaction; computer program /software; computer simulation; computer system design /evaluation; mathematical model; mechanical pressure; model design /development; nickel; swine; titanium

Nitinol, a shape memory alloy, provides a unique combination of properties which is particularly suited for medical devices. It is the material of choice for many stenting applications in treatment of vascular diseases. At the present time, there is no software available for mathematical modeling of thermomechanical behavior of Nitinol. The specific objective of this work is: To develop a CAD system based on mathematical models of Nitinol that can predict the mechanical response of medical devices under in vivo and in vitro conditions. To develop mathematical models of living tissues which are in contact with these devices, and to model the interactions (contact) between the medical devices and the living tissues in the context of nonlinear finite element. To design and fabricate new Nitinol stents with different design parameters for carotid, iliac and femoral applications utilizing the developed CAD system. To perform in vitro experimental studies for characterization of material parameters of Nitinol and the above arteries which are needed for mathematical modeling and verification of the software. To perform in vivo animal studies to examine acute and chronic response of the above arteries to various stent designs and to examine critical design parameters for Nitinol stents. PROPOSED COMMERCIAL APPLICATION: There are several potential commercial opportunities in this work. The market for stenting of various arteries is rapidly increasing and many biomedical companies will be very interested in this software. The software can be used for design of new medical devices, particularly Nitinol stents, with improved performance and higher reliabilities targeted for specific applications.

镍钛诺是一种形状记忆合金，具有独特的组合性能，特别适用于医疗设备。它是血管疾病治疗中许多支架应用的首选材料。目前，还没有可用于镍钛诺热力学行为数学建模的软件。本工作的具体目标是：开发一个基于镍钛诺数学模型的CAD系统，用于预测医疗器械在体内和体外条件下的机械响应。建立与这些设备接触的活组织的数学模型，并在非线性有限元的背景下对医疗设备与活组织之间的相互作用（接触）进行建模。利用已开发的CAD系统，设计和制造不同设计参数的新型镍钛诺支架用于颈动脉、髂动脉和股动脉。进行镍钛诺材料参数表征的体外实验研究以及上述动脉的数学建模和软件验证所需的实验研究。进行体内动物研究，以检查上述动脉对各种支架设计的急性和慢性反应，并检查镍钛诺支架的关键设计参数。建议的商业应用：在这项工作中有几个潜在的商业机会。各种动脉支架植入术的市场正在迅速增长，许多生物医学公司将对该软件非常感兴趣。该软件可用于设计新的医疗设备，特别是镍钛诺支架，具有针对特定应用的改进性能和更高的可靠性。