Two Coil Arterial Spin Labeling Cerebral Perfusion MRI

描述（由申请人提供）：脑血流量（CBF）定义速率 代谢底物的传递，是大脑代谢的中心。一 因此，测量局部脑血流的非侵入性方法 重要的是评估与大脑中的改变相关的病理学 代谢，如颈动脉狭窄，中风和脑肿瘤，以及 至于研究精神疾病和药物滥用。在这项研究中，我们将开发 并评估用于区域CBF的新型MR硬件的可行性， 人体灌注区域图。 新的动脉自旋标记（ASL）技术用于脑灌注和 灌注区域映射建议将建立在我们的初步MR 连续的动脉自旋标记（cASL）工作提供了第一个 能够在3T下在人体中执行cASL的系统。为了实现这一目标，我们将 验证了采用单独选通的OW AF源的方法的可行性 可以灵活地连接到GE或西门子扫描仪， 磁性标记流入血液的可解调自旋标记线圈， 与可解调头部线圈结合使用，以消除 成像和标记系统。建议的系统将改善MR 灌注测量：1）提供磁化无转移技术 允许采集多切片、任意平面、定量MR 灌注图。2)提高敏感性和覆盖面， 使用高效标记线圈的主动脉，从而实现多线圈cASL 将在3T下标记后循环和前循环的方法。 连续ASL方法先前已被限制为1.5T， 不安全的射频功率需求。3)独立标记每个颈动脉 以允许绘制其灌注区域并评估侧支 流 拟定商业应用： 通过MRI进行脑灌注测量是一种相对较新但发展迅速的方法 一种研究改变局部或整体大脑功能的多种疾病的方法 血流我们计划使双线圈动脉自旋标记系统可用 这是第一次，超过200个神经成像研究站点。我们计划继续 基于"仅供研究使用"器械成功的临床产品。

DESCRIPTION (Provided by Applicant): Cerebral blood flow (CBF) defines the rate of delivery of metabolic substrates and is central to brain metabolism. A non-invasive method for measuring regional cerebral blood flow is therefore important for assessing pathologies associated with alterations in cerebral metabolism such as carotid artery stenosis, stroke, and brain tumors, as well as for studying mental illnesses and drug abuse. In this study we will develop and assess the feasibility of a novel MR hardware for regional CBF and perfusion territory mapping in humans. The novel Arterial Spin Labeling (ASL) technique for cerebral perfusion and perfusion territory mapping proposed will build on our preliminary MR continuous Arterial Spin Labeling (cASL) work which has provided the first system capable of performing cASL in humans at 3T. To achieve this, we will validate the feasibility of a method employing a separately gated OW AF source that can be flexibly interfaced to GE or Siemens scanners and an independently detunable spin-labeling coil to magnetically label inflowing blood water for use in conjunction with a detunable head coil to eliminate interactions between the imaging and labeling systems. The proposed system will improve the MR perfusion measurements by: 1) Providing a magnetization transfer-free technique allowing the acquisition of multi-slice, arbitrary plane, quantitative MR perfusion maps. 2) Improving sensitivity and coverage by covering all of the major arteries with an efficient labeling coil, thus enabling a multi-coil cASL method that will label both posterior and anterior circulation at 3T. Continuous ASL methods has previously been limited to 1 .5T by potentially unsafe RF power demands. 3) Independently labeling each of the carotid arteries to allow the mapping of their perfusion territory and assessing collateral flow. PROPOSED COMMERCIAL APPLICATION: Cerebral perfusion measurements by MRI are a relatively new but rapidly growing method for studying a wide range of disorders that alter local or global cerebral blood flow. We plan to make the two coil arterial spin labeling system available for the first time, to the over 200 neuroimaging research sites. We plan to pursue a clinical product based on the success of the "investigational use only" device.