Does remote ischemic preconditioning induce protective mitochondrial function in congenital heart defect repair surgery?

人体自身的保护机制，防止因血流减少（缺血预处理）造成的损伤，已经研究了20多年，但直到最近才实现临床益处。我们以前已经证明，这种先天性保护可以在没有药物的情况下诱导心脏手术的儿童。我们将扩展这些发现，以确定保护机制，开发一种方法来监测血细胞中的保护作用，并看看这是否与术后结果有关。

The body's own protective mechanism against injury due to reduced blood flow (ischemic preconditioning) has been studied for over 2 decades, yet the clinical benefits have not been realised until recently . We have previously shown that this innate protection can be induced without drugs in children having heart surgery. We will extend these findings to determine the mechanism of protection, develop a method to monitor this in blood cells and see if this is related to post-operative outcomes.