Composite HA-Alumina Implants with Biomimetic Properties

在第一阶段的工作中，我们将展示基于患者特异性计算机轴向断层扫描（CAT）扫描数据的生物相容性双组分生物陶瓷几何形状的快速制造。生物陶瓷设备将在计算机指导下从纳米相和高纯度生物陶瓷细丝构建，而不需要使用改进的双进料熔融沉积建模（TM）（FDM）方法的硬工具。对于用于替换患病或创伤性受损的牙齿或骨骼部分的植入物，必要的要求是植入物与天然组织形成稳定的结合，并且在长期内产生可接受的宿主反应。Javelin提出的研究的主要目标是展示和扩大一种材料设计方法，用于直接和快速制造符合这些标准的双组分生物陶瓷植入物。拟议的商业应用：骨替代品是必要的，以帮助修复或替换受损，患病或缺失的骨组织。每年有超过500，000名患者需要骨移植。由于人口老龄化，寿命更长，世界范围内获得医疗保健的机会更多，骨移植系统的市场很大，估计为8.2亿美元，每年增长率为10%至20%。

During this Phase I effort, we will demonstrate the rapid fabrication of biocompatible dual-composition bioceramic geometries based on patient-specific computed axial tomography (CAT) scan data. The bioceramic devices will be built under computer guidance from both nanophase and high-purity bioceramic filament without the need for hard tooling using a modified Dual Feed Fused Deposition Modeling(TM) (FDM) approach. For implants that are used to replace diseased or traumatically- compromised dental or skeletal parts, a necessary requirement is that the implant form a stable bond to natural tissue and that over the long term, an acceptable host response results. The major goal of the research proposed by Javelin is to demonstrate and scale-up a materials- by-design approach for direct and rapid fabrication of dual-composition bioceramic implants that meet these criteria. PROPOSED COMMERCIAL APPLICATIONS: Bone substitutes are necessary to help repair or replace damaged, diseased, or missing bone tissue. Each year over 500,000 patients will require bone grafts. Due to an aging population that is living longer and a greater access to medical care worldwide, there is a large market for bone graft systems, estimated at $ 820 million, with growth rates of 10 to 20% per year.