CT-Integrated System for Precision, High-Yield Allograft Production

用于精密、高产量同种异体移植生产的 CT 集成系统

• 批准号: 7394853
• 负责人: Eugenie Alair Emory
• 金额: $ 9.54万
• 依托单位: JAVELIN DIGITAL DESIGN
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394853
• 关键词: Accountability; Adopted; Adoption; Allografting; American; Area; Biological; Biology; Bone Tissue; Bone Transplantation; Businesses; Caring; Cataloging; Catalogs; Ceramics; Cities; Code; Complex; Computer software; Computers; Condition; Consumption; Custom; Data; Databases; Dental; Development; Documentation; Donor Selection; Elements; Employee; Engineering; Equipment; Evaluation; Excision; Generations; Gifts; Goals; Grant; Health Care Costs; Human; Image; Imagery; Implant; Individual; Industry; Injury; Judgment; Library Catalogs; Link; Location; Measures; Mechanics; Medical; Medical Imaging; Metals; Methodology; Methods; Modeling; Modification; Molds; Morals; Morphologic artifacts; Musculoskeletal; Nature; Numbers; Operative Surgical Procedures; Orthopedic Procedures; Participant; Patients; Phase; Plastics; Procedures; Process; Production; Protocols documentation; Provider; Purpose; Quality of life; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Rights; Ritonavir; Scanning; Science; Screening procedure; Secure; Site Visit; Software Design; Solid; Spinal Fusion; Sports; Sterilization for infection control; Surface; Surgeon; System; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissue Banks; Tissue Donors; Tissues; Transplantation; Trauma; United States National Institutes of Health; Urination; Weight; Work; X-Ray Computed Tomography; age related; allogenic bone transplantation; base; bone; cost; density; design; digital; human tissue; image reconstruction; image visualization; imaging Segmentation; improved; instrument; instrumentation; manufacturing process; mathematical algorithm; new technology; programs; reconstruction; skills; soft tissue; software development; technological innovation; tissue preparation; wasting

DESCRIPTION (provided by applicant): The specific aim of this research grant request is to create a software manufacturing package for the production of allografts from donor bone tissue using an expert design basis that merges advances in 3D medical imaging and reconstruction software with traditional machining operations. Current methodology for allograft bone donor material involves removal of soft tissue followed by sectioning into blanks. Donor blanks are then machined to specific geometry using lathes and mills. After required assembly steps, the donor bone undergoes sterilization. This approach, which relies heavily on operator judgement, results in high material consumption. This greatly increases the cost of production, and, given the high- demand for bone allograft implants and the moral implications of working with human donor "gifts", current manufacturing approaches require modification.

描述(申请人提供)：这项研究资助申请的具体目标是利用专家设计基础创建一个软件制造包，用于从供体骨组织生产同种异体移植物，该设计基础将3D医学成像和重建软件的先进技术与传统的机械加工操作相结合。目前同种异体骨移植供骨材料的方法包括去除软组织，然后切成空白。然后用车床和磨床将施主毛坯加工成特定的几何形状。在所需的组装步骤之后，供体骨经历灭菌。这种方法严重依赖操作员的判断，导致材料消耗较高。这大大增加了生产成本，鉴于对同种异体骨移植植入物的高需求，以及与人类捐赠者“礼物”合作的道德含义，目前的制造方法需要修改。