VIBROMETER FOR ANIMAL TESTING

描述：（来自申请人的摘要）一个传统的定量 周围神经病变的动物测定包括测量动物的 有害热刺激的行为阈值限制本 热激活的感觉群体大部分是 无髓鞘;因此，与直接电生理记录的相关性是 非常困难和耗时。或者，单丝测试 提供了一个大的感觉阈值的排名， 机械感觉轴突，相对容易记录和识别 组织学上此外，最近的证据支持这样一种概念， 机械感受器感觉通路参与慢性疼痛的信号传导。的 开发一种刺激程序， 单丝测试将有利于外周神经行为学研究 感觉神经病（例如，糖尿病、烧伤、压迫和艾滋病），以及 开发治疗慢性疼痛的新药，以及基本的 研究遗传学和神经生物学。神经科学研究提出， 商业开发模型系统，具有标准程序和 在动物模型中使用机械感觉相关神经病变的量化仪器。 第一阶段将在周围神经病变的动物模型中测试系统的可行性 表现出机械性异常性疼痛（对机械性诱发的阈值降低 疼痛）。 拟定商业应用： 量化动物周围神经病变的仪器市场包括许多基本的 和应用研究实验室;例如，那些参与遗传学，神经科学， 周围神经发育和功能的神经生物学研究;药学 公司筛选化合物，以治疗急性和慢性疼痛，以及 神经毒性;和研究周围神经病变的实验室（例如，艾滋病糖尿病 压缩、化学神经毒理学）。

DESCRIPTION: (From the applicant's Abstract) One traditional quantitative animal assay for peripheral neuropathy involves measuring the animal's behavioral threshold to noxious thermal stimulation. A limitation of this approach is that thermally activated sensory populations are for the most part unmyelinated; hence, correlation with direct electrophysiological recording is extremely difficult and time-consuming. Alternatively, monofilament testing with hand-held probes provides a ranking of sensory threshold in large mechanosensory axons, which are relatively easy to record and identify histologically. In addition, recent evidence supports the concept that mechanoreceptor sensory pathways are involved in signaling chronic pain. The development of a stimulation procedure that is more quantitative than monofilament testing would be of benefit in behavioral studies of peripheral sensory neuropathy (e.g., diabetes, burn injury, compression, and AIDS), and development of new drugs for treatment of chronic pain, as well as basic investigations in genetics and neurobiology. Neuroscience research proposes the commercial development model system with standard procedures and instrumentation to quantify mechanosensory-related neuropathy in animal models. Phase I will test system feasibility in animal models of peripheral neuropathy that exhibit mechanical allodynia (diminished threshold to mechanically induced pain). PROPOSED COMMERCIAL APPLICATION: Markets for instrumentation to quantify animal peripheral neuropathy include numerous basic and applied research laboratories; e.g., those involved in genetic, neuroscience, and neurobiological studies of peripheral neural development and function; pharmaceutical companies screening for compounds to treat acute and chromic pain, as well as neurotoxicity; and laboratories studying peripheral neuropathy (e.g., AIDS, diabetic, compression, chemical neurotoxicology).