GENETIC /NUTRITIONAL FACTORS INFLUENCING EXTENT & PROGRESSION OF PROSTATE CANCER

这项拟议的研究旨在确定与前列腺癌的发展和/或程度相关的营养和遗传因素。大约150名新诊断的前列腺癌患者和150名按年龄和种族匹配的对照组将被招募。在选择进行前列腺切除术的病例子集中，其癌症的侵袭性将根据病理分期和分级来定义。目的是研究以下因素是否与前列腺癌的风险有关：(1)臀部脂肪组织中的脂肪酸组成：假设特定类别和/或个别脂肪酸与前列腺癌的病因有关。(2)人体测量(身体质量指数、腰臀比和体脂含量)：前列腺癌患者被假设为腰臀比和体脂百分比较高。(3)已知或推测与前列腺发育相关的遗传标记的种系多态：II5(-还原酶、雄激素受体、维生素D受体)和1号染色体长臂上的三个标记(1q24-25)。(4)血清维生素D水平：假设前列腺癌患者维生素D水平较低。

This proposed study aims to identify nutritional and genetic factors that are associated with the development and/or extent of prostate cancer. About 150 newly diagnosed prostate cancer patients and 150 controls matched to the cases by age and ethnicity will be recruited. Among the subset of cases who choose to have prostatectomy, the aggressiveness of their cancer will be defined by pathological stage and grade. The objective is to examine if the following factors are associated with the risk of prostate cancer: (1) Fatty acid composition in buttock adipose tissue: It is hypothesized that specific categories and/or individual fatty acids are associated with the etiology of prostate cancer. (2) Anthropometric measurements (body mass index, waist-hip ratio, and body fat content): Patients with prostate cancer are hypothesized to have a high waist-hip ratio and percent body fat. (3) Germline polymorphisms of genetic markers that are known or hypothesized to be associated with development of the prostate: type II 5(-reductase, androgen receptor, vitamin D receptor, and three markers on long arm of chromosome 1 (1q24-25). (4) Serum vitamin D levels: It is hypothesized that patients with prostate cancer have low vitamin D levels.