NUTRITION AND OBESITY--PHYSIOLOGIC MECHANISMS

关键是要确定和描述肥胖症的相关因素，以便制定干预措施，预防或扭转肥胖症的营养相关的负面健康后遗症。要做到这一点，需要更好地了解瘦-胖在决定人类食物摄入的机制方面的差异。本研究将表明肥胖个体是否能对与食物能量含量相关的内部生理线索作出反应。将准确表征和测量一天时间内体积操纵对食物和营养摄入的影响，以确定瘦和肥胖受试者是否可以补偿能量操纵，以及口服或胃内（IG）前负荷的体积是否对最佳食物选择或摄入产生差异性影响。该研究将测试以下假设：a）对于IG来说，必须存在体积和能量线索，以有效地减少随后的能量摄入。这将通过比较对各种能量存在的预负载和无预负载的能量调节响应来确定。B）肥胖个体对胃的机械和营养刺激的反应比瘦个体小。这将通过比较精瘦和肥胖个体在不同体积和能量密度的口服和IG预负荷后的能量调节反应来确定。

It is critical to identify and characterize factors involved in obesity, so that interventions to prevent or reverse the nutrition-related negative health sequelae of obesity can be developed. To do so requires a better understanding of lean-obese differences in the mechanisms that determine human food intake. The present study will indicate whether obese individuals can respond to internal physiological cues related to the energy content of foods. The effects of volume manipulations on food and nutrient intake over a one day period will be accurately characterized and measured to determine if lean and obese subjects can compensate for energy manipulations and if volume of the oral or intragastric (IG) preloads differentially affect subsequest food choice or intake. The study will test the following hypotheses: a)Both volume and energy cues will have to be present for IG to be effective in reducing subsequent energy intake. This will be determined by comparing the energy regulatory responses to various energy-present pre-loads and no pre-loads. b) Obese individuals will be less responsive to mechanical and nutrient stimulation of the stomach than lean individuals. This will be determined by comparing energy regulatory responses after oral and IG preloads of different volumes and energy densities in lean and obese individuals.