ROLE OF CISAPRIDE IN TREATMENT OF INFANTILE COLIC

目前的方案是随机、安慰剂对照、双盲 确定胃肠道药物西沙必利疗效的交叉试验 促动力，用于治疗婴儿绞痛。在研究期间 期间，父母不停地哭时间记录。初步统计结果 分析未能显示西沙必利与西沙必利有显著差异(0.87 +/-1.49小时[平均ISD]和安慰剂(1.36+/-1.33小时)或父母 主观评级。为了显示有效性，极大的样本量将 建议最低限度的药物疗效。在本研究期间18 受试者被招募，研究结束。

The current proposal is a randomized, placebo-controlled, double-blinded crossover trial to determine the efficacy of cisapride, a gastrointestinal prokinetic, for the treatment of infantile colic. During the study period, parents keep crying time logs. Results of initial statistical analysis failed to show significant differences between cisapride (0.87 +/- 1.49 hours [mean ISD] and placebo (1.36 +/- 1.33 hours) or parental subjective rating. To show efficacy an extremely large sample size would be required suggesting minimal drug efficacy. During this study period 18 subjects were enrolled and the study terminated.