ALCOHOL IN SIMPLE AND COMPLEX PERFORMANCES--SUBSTUDY A2

我们将研究酒精对工作表现的影响。 将不同剂量的酒精与安慰剂进行比较， 一系列的双盲交叉实验。咖啡因戒断 还将研究影响。此外，我们还将重点关注 男女对酒精的反应差异。设计将包括 测试女性在中期黄体与早期卵泡阶段的 月经周期虽然要收集关于一系列任务的数据， 重点放在性能在一个独特的实验模拟 提供有关白色运行的有效信息的设置 白领职业本研究的目的是1。审查 物质使用和滥用（咖啡因和酒精）对各种 白色领任务绩效方面，2.来阐明 血液水平和复杂性能之间的关系，3。到 确定物质剂量对复杂任务表现的影响， 4.为了确定物质戒断对任务表现的影响， 5.以确定在多大程度上平行的影响， 存在关于性能的更简单和更复杂方面的实质性内容， 和6.为了研究男女之间以及女性之间的周期 对酒精反应的差异，如果有的话，延伸到复杂的任务， 设置.将修改第三种刺激方案（根据需要）， 经验证，可提供更有效的治疗内比较 (e.g.,两种药物水平与安慰剂）条件下对项目1 6、如适用。

We will investigate the impact of alcohol on work related performance. Comparisons of diverse amounts of alcohol with placebo will employ a series of double-blind cross-over experiments. Caffeine withdrawal effects will also be investigated. In addition, we will focus on female-male differences in response to alcohol. The design will include testing of females at the mid luteal vs. early follicular phases of the menstrual cycle. While data on a range of tasks are to be collected, emphasis is placed on performance in a unique experimental simulation setting that provides validated information on functioning in white collar occupations. The proposed research is designed 1. to examine the effects of substance use and abuse (caffeine and alcohol) on various aspects of white collar task performance, 2. to elucidate possible relationships between blood levels and complex performance, 3. to determine the effects of substance dosage on complex task performance, 4. to determine the effects of substance withdrawal on task performance, 5. to determine the extent to which parallels in the effects of substances on simpler and on more complex aspects of performance exist and 6. to investigate whether male-female as well as female cycle differences in response to alcohol, if any, extend to complex task settings. A third stimulation scenario will be modified (as needed) and validated to provide for more efficient comparison of within treatment (e.g., two drug levels vs. placebo) conditions in research on items 1 through 6 as applicable.