SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT)

项目2(SPECT)将检查计算的单光子发射 两组受试者的断层扫描(SPECT)数据，以便 确定阿尔茨海默氏症发展的早期预测因素 疾病(AD)。第一组受试者(队列1)由 在上一个筹资周期内招募和跟踪的个人 165例。第二个样本(队列2)将在#年期间招募 下一个供资周期(n=106)。这两个队列都由对照组成 (CDR=0)和“可疑”AD受试者(CDR=0.05)。项目 2将收集这些参与者的数据，以确定SPECT 预测哪些受试者后来会进步到这一点的变量 他们符合AD的标准。来自项目2的数据也将 结合来自其他项目和核心的数据来确定 来自所有主要感兴趣领域的变量(例如， 神经心理学、SPECT、FMR、遗传学等)最能预测 AD的发展。

Project 2 (SPECT) will examine single photon emission computed tomography (SPECT) data in two cohorts of subjects, in order to identify early predictive factors for the development of Alzheimer's disease (AD). The first group of subjects (Cohort 1) consists of those individuals recruited and followed during the last funding cycle (n=165). A second sample (Cohort 2) will be recruited during the next funding cycle (n=106). Both cohorts consist of controls (CDR=0) and subjects with "questionable" AD (CDR=0.05). Project 2 will gather data on these participants in order to identify SPECT variables that predict which subjects will later progress to the point where they meet criteria for AD. Data from Project 2 will also be combined with data from other projects and Cores to determine the variables from all of the major domains of interest (e.e., neuropsychology, SPECT, fMR, genetics, etc) that best predict the development of AD.