SCREENING FOR ALZHEIMER'S AND PRECLINICAL ALZHEMER'S DISEASE

对社区进行阿尔茨海默病（AD）筛查将成为 作为新的和更有效的公共卫生优先事项 AD的治疗方法不断出现。临床前AD的筛查是一项 研究优先，了解早期过程的必要步骤 进行二级预防研究， 延迟或预防临床可诊断疾病的发作。这个项目 强调早期AD的电话筛查工具的有效性 和临床前AD在纵向人群为基础的背景下， study.我们建议管理我们的新型电话筛选电池， 目前最好的替代品（电话仪器， 认知状态：TICS，简易精神状态检查的电话版本） 从卫生保健金融中心招募的基于人口的样本 管理（HCFA）列表。受试者将收到电话电池 3次，间隔18个月。将进行全面的临床评估， 确定痴呆状态的横截面和随着时间的推移。我们将研究 手机电池的横截面和预测有效性。 虽然该项目测试电话筛选方法，但成功的 该区域将为使用其他模式进行筛选提供基础， 行政管理，包括面对面的面试。我们开发的工具 有希望立即用于研究应用，并为未来的公众 卫生干预措施。

Screening the community for Alzheimer's disease (AD) will become an increasingly important public health priority as new and more effective treatments for AD continue to emerge. Screening for preclinical AD is a research priority, a necessary step towards understanding the early course of the disease and conducting secondary prevention studies designed to delay or prevent the onset of clinically diagnosable disease. This project emphasizes the validation of telephone-based screening tools for early AD and preclinical AD in the context of a longitudinal population-based study. We propose to administer our novel telephone screening battery and the best currently available alternative (the Telephone Instrument for Cognitive Status: TICS, a telephone version of the Mini-Mental State Exam) to a population-based sample recruited from the Health Care Financing Administration (HCFA) lists. Subjects will receive the telephone battery 3 times at 18 month intervals. Full clinical assessments will follow to determine dementia status at cross-section and over time. We will examine the cross-sectional and predictive validity of our telephone battery. Although this project tests methods for telephone screening, success in this area will provide a foundation for screening using other modes of administration, including face-to-face interviews. The tools we develop have promise for immediate research applications and for future public health interventions.