CORE--BIOSTATISTICAL AND DATA MANAGEMENT

生物统计学/数据管理核心的目的是开发， 维护和保证项目数据库的完整性， 指导适当的统计分析， 节目的问题。 数据管理的具体目标和 生物统计学的核心是：1。创建、管理和保护项目数据 基础; 2.与项目科学家合作设计和分析 组成部分的研究;及3.发展新的统计方法， 这是对项目假设进行有效和高效推理所必需的。 数据库将在约翰霍普金斯威尔默研究所创建， 在专用微型计算机上进行维护，并带有磁带/盒式磁带备份。 资料将标准化，数据输入将得到核实，范围- 检查;每月总结报告将分发给研究者; 将每周进行备份，并将一份副本存放在场外。 统计分析将分三个阶段进行： 观察变量的单变量和多变量经验分布; 观察到的反应之间的关系的统计建模， 解释变量;以及将考虑以下因素的正式推论： 潜在变量和测量误差。 第一步和第二步将是 使用统计软件包S和SAS进行。 最后一步将 使用程序LISREL进行连续测量，但需要 方法论和计算机软件开发更普遍。

The purpose of the Biostatistics/Data Management core is to develop, maintain and guarantee the integrity of the program project data base and to direct appropriate statistical analyses to address the scientific questions of the program. The specific aims of the data management and biostatistics core are: 1. to create, manage and secure the project's data base; 2. to collaborate with project scientists in the design and analysis of the component studies; and 3. to develop new statistical methodology as necessary for valid and efficient inferences about project hypotheses. The data base will be created at the Johns Hopkins Wilmer Institute and maintained on a dedicated microcomputer with tape/cartridge backup. Questionnaires will be standardized, data entry will be verified and range- checked; monthly summary reports will be distributed to investigators; backups will be made weekly and one copy housed off-site. The statistical analysis will be conducted in three stages: exploration of univariate and multivariate empirical distributions of observed variables; statistical modelling of the relationship between observed responses and explanatory variables; and formal inferences which will take account of latent variables and measurement error. The first and second steps will be performed using the statistical packages S and SAS. The final step will use the program LISREL for continuous measures but will require methodologic and computer software development more generally.