Facility/Service Cores

设施/服务核心

• 批准号: 7434799
• 负责人: SCOTT L. ZEGER
• 金额: $ 17.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7434799
• 关键词: Address; Air Pollution; Allergens; Biological; Biological Markers; Blood; Carbon Black; Communities; Community Outreach; Core Facility; Development; Education and Outreach; Emergency Situation; Environmental Exposure; Environmental Health; Equipment; Exposure to; Funding; Gases; Goals; Health Sciences; Hearing; Isotopes; Lead; Mentors; Methods; Molds; Monitor; Numbers; Pilot Projects; Postdoctoral Fellow; Public Health Schools; Purpose; Research; Research Design; Research Infrastructure; Research Personnel; Sampling; Services; Source; Students; Testing; Trace Elements; Trace metal; Training; Universities; Work; air sampling; analytical method; design; human study; member; method development; outreach

A. Objectives, Rationale and Specific Aims The primary purpose of the Exposure Assessment Facility Core is to enhance the research capabilities of Center for Environmental Health in Northern Manhattan (CEHNM) investigators by providing expertise in a number of related activities and services not available elsewhere in the University, including exposure design, method development, sampling and analysis. This Facility Core supports the development and implementation of exposure assessments in support of funded research, pilot studies, new research initiatives, and outreach activities of the CEHNM by coordinating the following services and activities: ¿ study design, methods development, design and development of new sampling equipment, air sampling, and analytical capabilities; ¿ expansion of these facilities and efforts in ways that support the evolving strategic goals of the CEHNM; . ¿ training and mentoring of staff, students and researchers; ¿ responding to exposure emergencies; ¿ responding to the needs of the Community Outreach and Education Core (COEC) and local community ograniziations in a number of ways, including testifying in public hearings and carrying out pilot field work to test whether perceived sources of air pollution exist and can be documented. This Facility Core combines analytical capabilities and expertise at the Mailman School of Public Health (MSPH) and Lamont-Doherty Earth Observatory (LDEO). The primary focus of the Exposure Assessment Facility Core is on sampling and analysis of environmental rather than biological samples. The analysis of biomarkers of exposure are addressed by the Trace Metals Facility Core and the Integrative Health Sciences Facility Core, with the exception of lead isotope ratios in blood, which are analyzed at LDEO. A major strength of the CEHNM is the multiple working groups that are developing new initiatives and projects. Members of the Exposure Core participate in many of these groups to assist in the design of new exposure methods and markers that address specific research goals. The Specific Aims of the Exposure Assessment Facility Core are as follows: Specific Aim 1: To provide an infrastructure to assist CEHNM members and Pilot Project awardees carry out human studies of environmental exposures. The core will provide assistance in: a) Exposure assessment study designs; b) Design and development of new samplers; c) Development of analytical methods; d) Analysis of environmental samples for mass, black carbon, trace elements, isotope ratios, allergens, molds, gas concentrations, and trace organics); and e) Lending of monitoring equipment. Specific Aim 2: To provide mentoring and training to CEHNM members, students and postdoctoral fellows, and community partners.

A.目的、理由和具体目标 暴露评估设施核心的主要目的是提高研究能力， 北方曼哈顿环境健康中心（CEHNM）的调查人员通过提供专业知识， 大学其他地方没有的相关活动和服务的数量，包括曝光设计， 方法开发、取样和分析。 该基金核心支持风险评估的制定和实施，以支持 资助研究，试点研究，新的研究倡议，并通过协调CEHNM的推广活动 以下服务和活动： 研究设计，方法开发，设计和开发新的采样设备，空气 取样和分析能力; 以支持CEHNM不断发展的战略目标的方式扩大这些设施和努力; .工作人员、学生和研究人员的培训和指导; 应对暴露紧急情况; 响应社区外展和教育核心（COEC）和当地社区的需求 以多种方式组织，包括在公开听证会上作证和在实地开展试点 测试空气污染源是否存在并可记录在案。 该设施核心结合了梅尔曼公共卫生学院的分析能力和专业知识 Lamont-Doherty Earth Observatory（LDEO）暴露评估的主要重点 设施核心是环境而不是生物样本的采样和分析。分析 痕量金属设施核心和综合健康科学研究了暴露的生物标志物 设施核心，但血液中的铅同位素比率除外，该比率在LDEO进行分析。一个主要优势 CEHNM的多个工作组正在制定新的举措和项目。成员 Exposure Core参与了许多这样的小组，以协助设计新的曝光方法， 针对特定研究目标的标记。 暴露评估设施核心的具体目标如下： 具体目标1：提供基础设施以协助CEHNM成员和试点项目获奖者开展 人类环境暴露研究。该中心将在以下方面提供援助： B）设计和开发新的采样器; c）开发分析方法; d）分析 质量、黑碳、微量元素、同位素比、过敏原、霉菌、气体的环境样本 浓度和痕量有机物）;以及e）出借监测设备。 具体目标2：为CEHNM成员、学生和博士后研究员提供指导和培训， 和社区合作伙伴。