ALZHEIMERS DISEASE RESEARCH CENTER

这个阿尔茨海默病研究中心(ADRC)的目标是： Lindy Harrell，M.D.，Ph.D.和副董事Daniel Marson，J.D.， Michael Wyss医学博士)是培育一种临床和基础的模式 科学研究对阿尔茨海默病(AD)发病机制的影响。 该ADRC由5个核心和4个“R01”型项目组成。这个 行政矿石将提供所有可见性的实施 通过试点拨款(即引入新的调查人员)，每月 研讨会系列以及与其他ADRC/ADCC的互动。临床核心 将招募和每年跟踪轻中度AD患者和 正常对照组，由2名神经科医生诊断(受试者25%为非洲人- 美国人，75%是白人，杰斐逊县的种族混血儿)，将 提供1)生物统计服务，2)组织收集，3) 患者为调查人员。神经心理电池，提供 调查人员要求进行的额外神经心理测试，以及 开发分析纵向数据的方法。神经病理核心 将获得诊断、处理和存储组织(脑、脑脊液)，使 这些都是调查人员可以获得的。信息传输核心将提供 对医生、非专业人员和副专业人员社区的教育(与 强调非洲裔美国人)，维持发言人局， 护理者通讯，AD信息包，增加1-800电话 继续我们一年一度的芝加哥商品交易所会议，在世界上增加一个主页 网络，并通过多媒体手段传播ADRC的研究。第一 三个“R01”项目在主题上与理解AD 患者会失去特定的能力。项目1将检查以下项目的绩效 在驾驶刺激器中了解AD患者的认知变化 与有缺陷的驾驶和随着时间的变化有关。项目2 将检查影响照顾者的行为问题，以确定是否 电话干预改变了他们的负担。项目3将研究 纵向经济能力丧失与其神经心理 支撑点。方案4的不同之处在于中性调节蛋白的作用 (它可能调节Na+，K+通道和神经营养因子)将被访问 在AD和衰老中。政府当局大力支持这个亚洲及太平洋发展研究委员会 从哲学上和经济上讲，支付全额工资(大约 46,000美元)，以及翻新大脑资源计划 太空(20万-25万美元)。UAB的ADRC将允许我们继续 我们在AD方面的临床和基础科学研究努力，将使我们能够 拓展到新的研究领域。

The goal of this Alzheimer's Disease Research Center (ADRC), (Director: Lindy Harrell, M.D., Ph.D., and Associate Directors Daniel Marson, J.D., Ph.D., Michael Wyss, M.D.) is to foster a model of clinical and basic science research effect into the pathology of Alzheimer's Disease (AD). This ADRC is comprised of 5 cores and 4 "R01" type projects. The Administrative ore will provide the implementation of all visibility through pilot grants (i.e., bring new investigators), and a monthly seminar series and interactions with other ADRC/ADCC. The Clinical Core will recruit and annually follow mild and moderate AD patients and normal controls, diagnosed by 2 neurologists (subjects 25% African- American, 75% white, the racial mixture of Jefferson County), will provide 1) biostatistical services, 2) tissue collection, and 3) patients for investigators. Neuropsychological battery, provide additional neuropsychological tests requested by investigators, and develop methods to analyze longitudinal data. Neuropathological Core will obtain diagnoses, process and store tissue (brain, CSF), making these available to investigators. Information Transfer Core will provide education to physicians, lay and paraprofessional communities (with emphasis on African-Americans), maintained a Speakers Bureau, caregiver's newsletter, packets of AD information, add a 1-800 telephone line, continue our annual CME conferences, add a home page on the World Web, and disseminate ADRC research through multimedia means. The first three "R01" projects are thematically linked to understanding how AD patients lose specific capacities. Project 1 will examine performance of AD patients in a driving stimulator to understand the cognitive changes associated with defective driving and the changes over time. Project 2 will examine behavioral problems impacting caregivers to determine if telephone interventions modify their burden. Project 3 will examine the longitudinal loss of financial capabilities and their neuropsychological underpinnings. Project 4 differs in that the effects of neuregulins (which may regulate Na+, k+ channels and neurotrophins) will be accessed in AD and aging. The Administration strongly supports this ADRC both philosophically and financially, paying full salary (approximately $46,000) of the Administrator, and renovating Brain Resource Program space ($200,000-250,000). An ADRC at UAB would allow us to continue both our clinical and basic science research efforts in AD and would allow us to expand into new research areas.