CORE--ANIMAL MODELS

动物模型中心成立于1985年，由美国农业部 动物保护(DAC)。这一资源在 俄勒冈大学生物医学研究的持续增长和成功 健康科学大学通过减少复制的需要 设备、空间和支持人员。DAC增加了几个新的 自1985年以来一直是动物模型。1993年，第二只转基因小鼠 增加了实验室以满足OHS的额外要求 调查人员。核心设施的具体目标是：1)协助 癌症中心研究人员的发展和特征 生物医学相关动物模型；2)提供癌症中心 利用DNA显微技术研究无病原体转基因小鼠 注射和胚胎干细胞移植方法；3)提供 保持无病原菌的优质畜牧业计划 免疫缺陷动物模型，如裸鼠、裸鼠、SCID 小鼠，和受辐射的小鼠；4)保持转基因动物系 优质育种计划、检疫、种群再衍生，以及 冷冻保存；以及5)提供咨询和 对癌症中心研究人员进行转基因设计方面的培训 和其他动物模型研究。

The Animal Models Core was established in 1985 by the Department of Animal Care (DAC). The resource has played a major role in the continued growth and success of biomedical research at the Oregon Health Sciences University by reducing the need for duplication of equipment, space, and support staff. The DAC has added several new animal models since 1985. In 1993, a second transgenic mouse laboratory was added to meet additional requirements of OHS investigators. The specific goals of the Core facility are: 1) to assist Cancer Center investigators in the development and characterization of biomedically relevant animal models; 2) to provide Cancer Center investigators with pathogen free transgenic mice using DNA micro injection and embryonic stem cell transfer methods; 3) to provide a quality husbandry program for the maintenance of pathogen free immunodeficient animal models such as nude mice, nude rats, scid mice, and irradiated mice; 4) to maintain transgenic animal lines with quality breeding programs, quarantine, re-derivation of stocks, and cryopreservation; and 5) to provide a source of consultation and training to Cancer Center investigators about the design of transgenic and other animal model studies.