CENTER FOR DIGESTIVE AND LIVER DISEASES

这项修订后的消化系统疾病研究核心中心提案将联合 来自多个学科的调查人员，以达到新的水平， 消化生物学、病理生物学和治疗的整合。的 科学的重点是细胞生长的分子控制， 消化器官的分化及其相互关系 炎症和肿瘤性疾病的过程。研究基地是 通过讨论、交换试剂和 研究人员之间的科学合作。的数量 调查员从最初提议的35人减至26人 希望进一步发展互动研究小组的科学家们。 在科学重点范围内，已经形成了一些主题， 中心的研究人员一起，包括基因调控，炎症 和免疫学，以及细胞生长和肿瘤生物学的调节。四 科学核心已经开发，其目标是提供 消化特定的服务和试剂， research.核心内容包括形态学、分子生物学、转基因 嵌合小鼠和载体。行政核心将由以下人员领导： 导演Peter G. Traber和科学/副主任， 丽贝卡·A特劳布该核心将指导财务和组织 该中心的各个方面，包括制定浓缩方案 和电子通信。已选定试点/可行性项目 根据其与科学重点的相关性和 在年轻的研究者中推广消化系统研究。的建议 包括：1）负责Alagille的基因的定位克隆 综合征，2）肠发育中的PRL-1，3）诱导和 非洲爪蟾内胚层谱系的模式化，以及4）反应 综合征除了这些提案的主要研究者外， 会有一批优秀的年轻调查员 来自宾夕法尼亚大学消化疾病中心。在 总结，这一修订后的建议提供了证据，新生的 中心两年前提出，现已成熟，发展成为一个实体 在大学科学界内。大学 宾夕法尼亚州准备充分利用资金， 消化系统疾病研究核心中心。

This revised Digestive Diseases Research Core Center proposal will unite investigators from multiple discipline to achieve a new level of integration in digestive biology, pathobiology, and therapy. The scientific focus is on the molecular controls of cellular growth and differentiation in digestive organs and on the relationship of these processes to inflammatory and neoplastic diseases. The research base was refined by a process of discussion, exchanges of reagents, and scientific collaborations between investigators. The number of investigators was decreased from 35 in the initial proposal to 26 scientists who want to further develop an interactive research group. Within the scientific focus, a number of themes have evolved which link Center investigators together, including gene regulation, inflammation and immunology, and regulation of cell growth and tumor biology. Four scientific Cores have been developed with the goals of providing digestive-specific services and reagents and stimulating collaborative research. The cores include Morphology, Molecular Biology, Transgenic and Chimeric Mouse, and Vector. An administrative Core will be led by the Director, Peter G. Traber, and the Scientific/Associate Director, Rebecca A. Traub. This Core will direct the financial and organizational aspects of the center, including development of an enrichment program and electronic communications. Pilot/Feasibility Projects were selected based on their relevance to the scientific focus and the priority of promoting digestive research among young investigators. The proposals include: 1) positional cloning of the gene responsible for the Alagille Syndrome, 2) PRL-1 in intestinal development, 3) induction and patterning of endodermal lineages in Xenopus laevis, and 4) response syndrome. In addition to the Principal Investigators of these proposals, there is a cadre of outstanding young investigators who will benefit from a Digestive Diseases Center at University of Pennsylvania. In summary, this revised proposal provides evidence that the nascent Center proposed two years ago has matured and developed into an entity within the University scientific community. The University of Pennsylvania is poised to take excellent advantage of funding for a Digestive Disease Research Core Center.