EFFECTS OF ISOPROTERENOL & ADENOSINE ON AUTONOMIC NERVOUS SYSTEM

由于心律失常深受自主神经张力的影响，异丙肾上腺素和腺苷是心脏电生理实验室必不可少的工具。通常只有在异丙肾上腺素冲洗期间才会引起心律失常。通过研究在输注异丙肾上腺素之前、期间和之后自主神经张力的变化，研究人员希望确定在冲洗期间是否发生了交感神经-迷走神经平衡的独特阶段，这可以解释这一诱导窗口。由于腺苷首先引起抗肾上腺素能变化，然后引起拟交感神经变化，因此本研究将描述两者的时间过程，并允许在心脏电生理实验室中对腺苷产生的自主神经变化进行最佳利用。进展报告和结果总结：20例患者进行了研究。所有患者均完成了监测交感神经记录、血压和心率变异性的方案，包括在输注异丙醇和给药腺苷之前、期间和之后。

Because arrhythmia are profoundly influenced by autonomic tone, isoproterenol and adenosine are essential tools in the cardiac electrophysiology laboratory. Frequently arrhythmia are induced only during isoproterenol washout. By studying changes in autonomic tone before, during and after infusion of isoproterenol, the investigators expect to determine if a unique phase of sympatho-vagal balance occurs during washout which could explain this window of inducibility. Because adenosine causes first antiadrenergic changes and then sympathomimetic changes, this study will delineate the time course of both and allow optimum utilization in the cardiac electrophysiology laboratory of the autonomic changes produced by adenosine. Progress report and summary of findings: Twenty patients were studied. All completed the protocol consisting of monitoring sympathetic nerve recordings, blood pressure and heart rate variability before, during and after infusion of isoproteranol and administration of adenosine.