STEM CELL RESCUE AFTER BONE MARROW CURETTAGE FOR TREATMENT OF AMM

不明原因的髓样化生(AMM)是一种进行性的、无法治愈的疾病，由骨髓纤维化引起，并伴有不可抗拒的脾肿大和外周血白细胞。通过从股骨和髂骨中去除纤维/骨硬化性物质，并注入自体干细胞，希望通过恢复造血来实现持续的血液学任务。进展报告和结果总结：在7名患者中，1名患者术后死亡(死于与手术无关的事件)，1名患者在术后11个月死亡，无反应，1名患者在术后3个月无反应。脾切除的指征是进行性脾肿大或输血需求增加。在两名有明显脾肿大的患者中，没有发生消退。在这两例中，一例随后需要切除脾，另一例仍有增大的脾。在两名需要大量输血的患者中，手术前两人现在都不需要输血，其中一个红细胞压积约为36%，另一个约为34%。

Agnogenic myeloid metaplasia (AMM) is a progressive and incurable disease caused by fibrosis of the bone marrow and accompanied by inexorable splenomegaly and leukothroblastic peripheral blood picture. By removing the fibrotic/ osteosclerotic substance from a femur and iliac crest and infusing autologous stem cells it is hoped that a sustained hematological mission owing to restored hematopoiesis will occur. Progress report and summary of findings: Of the seven patients, one died post-operatively (from an unrelated operative event), one died eleven months post-operatively and had no response, and one patient has had no response three months post-operatively. The indications for splenectomy were either progressive splenomegaly or increase in transfusion requirements. Of the two patients with significant splenomegaly, regression has not occurred. Of the two, one subsequently required splenectomy and the second still has an enlarged spleen. Of the two patients with significant transfusion requirements, pre-operatively, both are now free of the need for transfusion with one hematocrit in the order of 36% and the other approximately 34%.