TOTAL DIETARY POTASSIUM DEPRIVATION AND ENERGY EXPENDITURE OF HEALTHY SUBJECTS

虽然肥胖是热量摄入过多和身体活动不足的结果，但生理和代谢因素也起作用。血清钾浓度的变化与静息代谢率（RMR）的变化呈正相关。 膳食钾摄入可能通过刺激钠泵（Na+-K+-ATP酶）从而提高RMR而在能量消耗中起作用。 由于这在体重调节中具有重要意义，因此我们希望在其他宏量和微量营养素保持不变的情况下，在较长时间的膳食钾剥夺后，更广泛地研究膳食钾对RMR的影响。幸运的是，我们目前的协议之一，在临床研究中心，“精氨酸加压素，钾排泄和酸碱平衡”是在进行零钾饮食的过程中。 它比较了9天的正常钾饮食与11天的零钾和11天的高钾饮食，这些饮食具有相同的宏观和微观营养素以及纤维。 RMR的测量将进一步深入了解膳食钾和总能量消耗之间的关系。

Though obesity is the result of excessive caloric intake and inadequate physical activity, physiological, and metabolic factors also play a role. Positive correlation between changes in serum K concentration and changes in Resting Metabolic Rate (RMR) have been shown. Dietary potassium intake may possibly play a role in energy expenditure by stimulating the sodium pump (Na+-K+-ATPase) and thus elevating the RMR. Since this has an important implication in weight regulation we would like to investigate the effect of dietary potassium on RMR more extensively after a longer period of dietary K deprivation with other macro and micro nutrients kept constant. Fortunately, one of our current protocols in the Clinical Research Center, "Arginine Vasopressin, Potassium Excretion and Acid-Base Balance" is in the process of conducting a zero K diet. It compares a nine day normal K diet to 11 days of zero K and 11 days of high K with the same macro and micro- nutrients as well as fiber. Measurements of RMR will additionally provide insight into the relationship between dietary K and total energy expenditure.