COMPARISON OF SAQUINAVIR GELATIN FORMULATION IN HIV PATIENTS

沙奎那韦是一种新药，其作用方式与另一种药物不同 一组抗艾滋病毒药物，逆转录酶抑制剂(包括 Azt、ddC、ddi和d4T)。沙奎那韦通过以下方式干扰病毒产生 抑制HIV病毒形成所需的一种酶“蛋白水解酶” 蛋白质。CD4细胞，也被称为T辅助细胞，是至关重要的 免疫系统中的细胞，是艾滋病毒的主要目标。有两个 这种研究用药物的剂型。第一种是沙奎那韦，它来自 在硬凝胶胶囊中，第二种也是新的是SQV-SGC，它在一个 软凝胶胶囊。这项研究的目的是比较这些活动 SQV(硬凝胶胶囊)600的抗HIV、安全性和药代动力学 给SQV-SGC(软胶囊)400 mg、800 mg和1200 mg 连续4周，每8小时张口一次。

Saquinavir is a new drug which works in a different way from another group of anti-HIV drugs, the reverse transcriptase inhibitors (including AZT, ddC, ddI and d4T). Saquinavir interferes with virus production by inhibiting an enzyme "proteinase" which is needed by HIV to form viral proteins. The CD4 cell, also known as the T helper cell, is the critical cell in the immune system and is a major target of HIV. There are two forms of this investigational drug. The first is Saquinavir which comes in a hard gel capsule, the second and new is SQV-SGC which comes in a soft gel capsule. The purpose of this study is to compare the activity against HIV, safety, and pharmacokinetics of SQV (hard gel capsule) 600 mg, to SQV-SGC (soft gell capsule) 400 mg, 800 mg and 1200 mg given by mouth every 8 hours for 4 weeks.