NIMH CENTER FOR GENETIC STUDIES

遗传因素在重症肌无力家族聚集性中的作用 脑功能紊乱得到了很好的支持。NIMH人类遗传学倡议 (http：//www-grb.nimh.nih.gov/gi.html）支持多学科和 合作研究项目，采用最先进的 诊断程序和分析方法，以收集大量样本 精神分裂症和情绪的遗传分析 紊乱收集的全面临床数据和生物材料 该倡议将由NIMH广泛提供给合格的 科学界的研究人员进行基因分析， 目的是鉴定赋予这些疾病易感性的基因。 该合同的主要目标是建立NIMH中心 遗传学研究，这将实现以下目标：（1）接收 临床、诊断、谱系结构和其他数据以及血液 来自NIMH支持的人类遗传学项目的样本， 确定多个受影响个体的谱系 精神分裂症、情绪障碍或其他精神障碍;（2）过程 数据，以创建表型信息的电子数据库， 在遗传分析中;（3）从接收的血液转化淋巴细胞 样本来创建高质量的细胞系，从中DNA将被 （4）将这些数据和生物材料与 NIMH人类遗传学中的可比现有数据和生物材料 （5）接受来自基因分析的数据， 人类遗传学倡议中的生物材料;（6）广泛 分发所有表型和基因型数据以及生物材料 (cell线和DNA样本），在NIMH人类遗传学倡议 科学界的合格研究人员。

The role of genetic factors in the familial aggregation of serious brain disorders is well supported. The NIMH Human Genetics Initiative (http://www-grb.nimh.nih.gov/gi.html) supports multidisciplinary and collaborative research projects, employing state-of-the-art diagnostic procedures and analytic methods, to collect large samples of pedigrees for genetic analyses of schizophrenia and mood disorders. Comprehensive clinical data and biomaterials collected in this Initiative will be made widely available by NIMH to qualified investigators in the scientific community for genetic analyses that aim to identify genes conferring susceptibility to these disorders. The main objective of this contract is to establish the NIMH Center for Genetic Studies, which will accomplish the following: (1) receive clinical, diagnostic, pedigree structure, and other data and blood samples from NIMH-supported human genetics projects, which will ascertain pedigrees with multiple individuals affected with schizophrenia, mood disorders, or other mental disorders; (2) process data to create electronic databases of phenotypic information for use in genetic analyses; (3) transform lymphocytes from received blood samples to create high-quality cell lines, from which DNA will be extracted; (4) incorporate these data and biomaterials with comparable existing data and biomaterials in the NIMH Human Genetics Initiative; (5) receive data derived from genetic analyses of biomaterials in the Human Genetics Initiative; and (6) widely distribute all phenotypic and genotypic data, as well as biomaterials (cell lines and DNA samples), in the NIMH Human Genetics Initiative to qualified investigators in the scientific community.