CORE--FERMENTATION

发酵共享设施的总体目标是产生细胞和生物材料，这将加快癌症中心成员的研究工作。发酵共享设施为综合癌症协会的成员提供了大规模生产微生物、动物和昆虫细胞及其产品的能力，而这种规模在实验室是不经济的。该设施包括用于大规模细胞生长、细胞破坏、生物处理(纯化)和适当分析测量的设备的空间。细胞生长的规模从8升到400升，而细胞破裂的规模从100毫米到40升。此外，该设施还提供几种菌种、一种动物细胞和两种蛋白质的生物量。该设施还提供生物材料生产和提纯方面的重要专业知识。从1997年10月1日至1998年9月30日，该设施为中心成员提供了128个发酵和生物加工单位。该设施被14个原则调查和17个资助项目使用。它们的使用在29种出版物中发挥了重要作用。发酵共享设施的使用率在运行的前12年有所增加，现在显然已经达到了某种程度上的恒定使用率。

The overall goal of the Fermentation Shared Facility is to generate cells and biologic materials which will expedite research efforts of Cancer Center members. The Fermentation Shared Facility provides members of the Comprehensive Cancer with the capability to produce microbial, animal and insect cells and their products on a scale that would be uneconomic in the laboratory. The facility consists of space with equipment for large-scale cell growth, for cell disruption, for bioprocessing (purification) and for appropriate analytical measurements. The scale for cell growth ranges from eight to four hundred liters, whereas that for cell disruption changes from one hundred millimeters to forty liters. In addition the facility makes available biomass of several stock strains of bacteria, one strain of animal cells and two proteins. The facility also makes available significant expertise in the production and purification of biological material. From October 1, 1997 to September 30, 1998, the facility provided 128 units of use by members of the Center for fermentation and bioprocessing. The facility was used by 14 principle investigations with 17 funded projects. Their use was instrumental in 29 publications. The usage of the Fermentation Shared Facility increased for the first 12 years of operation and now has apparently reached somewhat of a constant usage rate.