CORE--DIAGNOSTIC METHODS AND CASE REGISTRY CORE

此核心B主要负责协调和跟踪 它的核心B也有计划项目调查的主题 负责获取在入职期间收集的数据， 将这些数据输入方案项目数据库/数据档案，并用于 计划和跟踪数据采集和分析的进度 适用于所有项目。此核心被组织为一组服务- 基于子核，提供经济高效的集中化资源 基于服务的子核，提供经济高效的集中式 为五个项目提供资源服务。子核心如下： (1)诱导/筛选亚核将对所有人类进行筛选 计划项目的主题，其中包括收集医疗、 与诱导和应用有关的行为和背景记录 包容性/排除性标准； (2)行为诊断分核将负责采购和 分析与诱导相关的行为数据，包括 智力匹配的标准化测验和情感测量 用于匹配和应用的功能和家庭环境 包容性/排除性标准； (3)神经成像/企业资源规划分部将负责协调 为项目二和项目三研究获取企业资源规划和核磁共振数据； (4)脑尸检分核心将协调脑切除、组织 用于遗传分析的采购(与遗传样本协调 次级核心和项目III)、脑固定、核磁共振(与 神经成像分核心和项目二)，并转移到项目四 进行详细细胞结构分析的实验实验室； (5)遗传样本亚核将从所有WMS获取血液样本 受试者及其父母，输入有关样本的相关信息 捐献者到数据库并分配一个化名，邮寄血样用于 转换和存储，并将数据和DNA样本传输到项目V。 在所有子核中，核心B将负责组织高效的 与项目项目人员进行主题互动的时间表，允许 用于收集所有必要的数据。它还将跟踪数据之后 收集和处理，确保及时准确地录入 项目数据库/数据归档，并确保数据在 项目之间以及项目与核心之间。

This Core B has primary responsibility for coordination and tracking of subjects for the Program Project investigations it Core B also has responsibility for acquisition of data collected during induction, for entry of this data into the Program Project Database/Data Archives, and for scheduling and tracking the progress of data acquisition and analysis in general across all projects. This Core is organized into a set of service- based subcores which provide cost-efficient and centralized resource services-based subcores which provide cost-efficient an centralized resource services to the five Projects. The subcores are as follows: (1) Induction/Screening Subcore will perform the screening of all human subjects to the Program Project, which includes gathering of medical, behavioral, and background records relevant to induction and application of inclusionary/exclusionary criteria; (2) Behavioral Diagnostics Subcore will be responsible for acquisition and analysis of behavioral data associated with induciton, including standardized tests of intelligence for matching and measures of affective functioning and home environment for matching and application of inclusionary/exclusionary criteria; (3) Neuroimaging/ERP Subcore will be responsible for coordinating the acquisition of ERP and MRI data for Project II and Project III studies; (4) Brain Autopsy Subcore will coordinate brain removal, tissue acquisition for genetic analyses (in coordination with Genetic Samples Subcore and Project III), brain fixation, MRI (in coordination with Neuroimaging Subcore and Project II), and transport to the Project IV experimental laboratory for detailed cytoarchitectonic analysis; (5) Genetic Samples Subcore will obtain blood samples from all WMS subjects and their parents, enter pertinent information about the sample donors to the database and assign a pseudonym, mail the blood sample for transformation and storage, and transmit data and DNA samples to Project V. Across all subcores, Core B will be responsible for organizing an efficient schedule of subject interaction with Program Project personnel, allowing for collection of all necessary data. It will also track data after collection and processing to ensure timely and accurate entry to the Project Database/Data Archives, and to ensure efficient flow of data among Projects and between projects and cores.