INTERCYCLE STUDY

这项研究的目的是加深我们对正常女性生殖衰老过程的理解，特别是对卵巢多肽的研究。老年排卵期妇女卵泡刺激素单向性升高与正常卵泡大小和明显正常的卵巢激素分泌有关。这些老年妇女的卵泡发育似乎加快了，急性卵泡雌二醇上升的时间更早，促黄体激素的激增更早，排卵更早。这些发现表现为卵泡期缩短和总月经周期缩短。这项研究旨在通过使用促性腺激素释放激素激动剂抑制所有受试者的垂体促性腺激素分泌，然后研究停止抑制后的恢复反应，来进一步表征这种促性腺激素分泌的变化。

The goal of this study is to further our understanding of the reproductive aging process in the normal human female with special emphasis on the ovarian peptides. A monotropic rise in follicle stimulating hormone in older ovulatory women is associated with normal follicle size and apparently normal ovarian hormone secretion. These older women have what appears to be accelerated follicular development with earlier onset of the acute follicular estradiol rise, an earlier lutenizing hormone surge and earlier ovulation. These findings are manifested as a shortened follicular phase and a shortened total menstrual cycle length. This study is designed to further characterize this change in pituitary output of FSH by suppressing the pituitary gonadotropin secretion of all subjects using a gonadotropin releasing hormone agonist and then studying the recovery response after discontinued suppression.