EFFECTS OF ETHNICITY ON CYTOCHROME P450 IN HLTHY INDIVS USING MIDAZOLAM

关于种族对药物处置影响的可用数据很少。了解细胞色素P450 3A4酶（CYP3A4）的活性对多种外源性药物的代谢非常重要。咪达唑仑最近被研究为一种有吸引力的CYP3A4体内探针。口服和静脉注射咪达唑仑的药代动力学将在24名健康的非裔美国人和白种人中进行研究。

There is little available data on the effects of ethnicity on drug disposition. Understanding the activity of the cytochrome P450 3A4 enzyme (CYP3A4) is important to the metabolism of a wide variety of xenobiotics. Midazolam has recently been studied as an attractive in vivo probe for CYP3A4. The pharmacokinetics of oral and intravenous midazolam will be studied in twenty-four healthy African-American and Caucasian individuals.