COCAINE EXPOSED INFANTS--CARDIAC PROBLEMS AND OUTCOME

怀孕期间使用可卡因的母亲所生的婴儿发病率更高，猝死率更高。猝死的原因尚不清楚。初步观察提示存在多种心血管异常，如左心室重量增大、持续性高血压、ST段抬高和迷走神经张力增高。为了研究宫内可卡因暴露对心血管的影响，本研究的目的是：检测新生儿期的心血管异常，评估脐带血血浆胆碱酯酶活性与上述异常的关系，并研究这些异常在出生前2个月的自然病史。

Infants born to mother who use cocaine during pregnancy have greater morbidity and a higher rate of sudden death. The etiology of sudden death is unclear. Preliminary observations suggest the presence of multiple cardiovascular abnormalities such as greater left ventricular mass, persistent hypertension, greater prevalence of ST segment elevations and higher vagal tone. To study the cardiovascular effects on in-utero cocaine exposure the study has the following aims: to detect the cardiovasculaar abnormalities in the newborn period; to evaluate the relationship of cord blood plasma cholinesterase activity and the above abnormalities; and to study the natural history of these abnormalities during the first 2 months of life.