INSULIN REDUCTION AND OVULATION IN WOMEN WITH PCOS

本研究考察了使用二甲双胍药物降低胰岛素浓度对自发排卵和对柠檬酸克罗米芬药物反应的排卵的影响。我们知道，许多患有多囊卵巢综合征（PCOS）的女性不能自发排卵，而且通常对一种常用的促排卵药物——柠檬酸克罗米芬（Clomid）——的反应不佳。我们也知道，许多患有多囊卵巢综合征的女性血液中胰岛素浓度升高。如果通过饮食和运动降低胰岛素水平，多囊卵巢综合征的女性通常会开始自发排卵。然而，许多患有多囊卵巢综合征的女性发现很难减轻足够的体重和/或进行足够的运动来降低胰岛素水平。二甲双胍是一种已被证明可以降低胰岛素水平的药物，因此，可能被证明对患有多囊卵巢综合征但渴望生育的女性有用。我们希望了解，当血清胰岛素水平降低时，患有多囊卵巢综合征的肥胖妇女是否会有自发排卵率增加或克罗米芬刺激排卵率更高。

This study examines the effects of the reduction of insulin concentrations using the medication, metformin, on both spontaneous ovulation and on ovulation in response to the medication, clomiphene citrate. We know that many women with the polycystic ovary syndrome (PCOS) do not ovulate spontaneously and often do not respond well to a drug commonly used to induce ovulation known as clomiphene citrate (Clomid). We also know that many women with polycystic ovary syndrome have elevated insulin concentrations in their blood. If insulin levels are reduced with diet and exercise, women with PCOS often begin to ovulate spontaneously. However, many women with PCOS find it very difficult to lose enough weight and/or exercise enough to lower their insulin levels. Metformin is a drug that has been shown to lower insulin levels and, therefore, may prove to be useful in treating women with the polycystic ovary syndrome who desire fertility. We hope to learn whether obese women with the polycystic ovary syndrome will have an increased rate of spontaneous ovulation or a higher rate of clomiphene-stimulated ovulation when serum insulin levels are reduced.