A CAD SYSTEM FOR NICKLE-TITANIUM MEDICAL DEVICE

镍钛合金是一种形状记忆合金，具有独特的性能组合，特别适用于医疗设备。它是血管疾病治疗中许多支架应用的首选材料。目前，还没有可用的软件对镍钛醇的热机械行为进行数学建模。这项工作的具体目标是：开发一种基于镍钛醇数学模型的CAD系统，可以预测医疗器械在体内和体外条件下的机械响应。建立与这些设备接触的活组织的数学模型，并在非线性有限元的背景下模拟医疗设备与活组织之间的相互作用(接触)。利用开发的CAD系统设计和制造不同设计参数的新型镍钛合金支架，用于颈动脉、髂动脉和股动脉。对数学建模和软件验证所需的镍钛合金和上述动脉的材料参数进行体外实验研究。进行活体动物研究，以检查上述动脉对各种支架设计的急性和慢性反应，并检查镍钛支架的关键设计参数。拟议的商业应用：这项工作有几个潜在的商业机会。各种动脉支架的市场正在迅速增长，许多生物医学公司将对这一软件非常感兴趣。该软件可用于设计新的医疗设备，特别是镍钛支架，针对特定应用，具有更高的性能和更高的可靠性。

Nitinol, a shape memory alloy, provides a unique combination of properties which is particularly suited for medical devices. It is the material of choice for many stenting applications in treatment of vascular diseases. At the present time, there is no software available for mathematical modeling of thermomechanical behavior of Nitinol. The specific objective of this work is: To develop a CAD system based on mathematical models of Nitinol that can predict the mechanical response of medical devices under in vivo and in vitro conditions. To develop mathematical models of living tissues which are in contact with these devices, and to model the interactions (contact) between the medical devices and the living tissues in the context of nonlinear finite element. To design and fabricate new Nitinol stents with different design parameters for carotid, iliac and femoral applications utilizing the developed CAD system. To perform in vitro experimental studies for characterization of material parameters of Nitinol and the above arteries which are needed for mathematical modeling and verification of the software. To perform in vivo animal studies to examine acute and chronic response of the above arteries to various stent designs and to examine critical design parameters for Nitinol stents. PROPOSED COMMERCIAL APPLICATION: There are several potential commercial opportunities in this work. The market for stenting of various arteries is rapidly increasing and many biomedical companies will be very interested in this software. The software can be used for design of new medical devices, particularly Nitinol stents, with improved performance and higher reliabilities targeted for specific applications.