NOVEL APPROACH TO TIPS: STENT POLYMER PAVING COMPOSITES

尖端的新方法：支架聚合物铺路复合材料

• 批准号: 6292598
• 负责人: M PANAHANDEH
• 金额: $ 9.28万
• 依托单位: BERKELEY APPLIED SCIENCE AND ENGINEERING
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6292598
• 关键词: bioengineering /biomedical engineering; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; blood vessel prosthesis; liver circulation; medical implant science; polymers

DESCRIPTION (Verbatim From Applicant's Abstract): In the management of cirrhotic patients with variceal bleeding, transjugular intra-hepatic portosystemic shunt (TIPS) plays an important role in decompressing the portal system and preventing the danger of frequent rebleeding. The advance of this less invasive, non-surgical approach of portal decompression was made possible through the clinical introduction of vascular stents. At first, balloon expandable stents, such as Palmaz stents or Tantalum Strecker stents were employed in TIPS procedure, however, in time, many switched to self-expanding stents such as Wallstent, Nitinol Stecker stents, Memotherm stents, or GianturcolRosch stents, which became more popular due to their easier deployment and variety of size available. However, there are intrinsic differences among all self-expanding stents regarding elasticity, length, diameter, longitudinal flexibility hoop strength, mesh profile, and delivery system, which influence their performance. Despite the clinical success of TIPS to date, several major challenges remain. Early malfunction of TIPS may occur due to tract closure resulting from bioleakage intralumina! thrombosis, incomplete stent expansion, or stent migration. More commonly, TIPS patency is compromised progressively in the months following placement due to tissue in-growth. These and other limitations of current TIPS practice must be resolved to ensure durable patency and efficacy rates for TIPS. It is the specific objective of this Phase I project to resolve some of these limitations through introduction of a composite nitinol stent combined with in adherent polymeric endoluminal layer. Berkeley Applied Science & Engineering, Inc. (BASE) has developed a unique expertise in using nitinol for various industrial and medical applications. The co-investigator, Dr. Slepian, was the original inventor and developer of polymeric endoluminal paving. During Phase l.a combination of strengths will be utilized, including mathematical simulation of BASE and the polymeric expertise of the Slepian lab. Prototype stent samples will be fabricated and a limited animal study will be done to demonstrate how present limitations of TIPS procedure can be improved. PROPOSED COMMERCIAL APPLICATION: Not Available

描述（逐字摘自申请人摘要）： 经颈静脉肝内静脉曲张破裂出血患者 门体分流术（TIPS）在门静脉减压中起重要作用 系统和防止频繁再出血的危险。这一进步 微创、非手术的门静脉减压术成为可能 通过血管支架的临床应用。一开始，气球 可扩张支架，如Palmaz支架或钽Strecker支架， 然而，随着时间的推移，许多人转而使用自膨胀式 支架，例如Wallstent、镍钛诺Stecker支架、Memotherm支架，或 GianturcolRosch支架，由于其更容易 部署和各种尺寸可用。然而，有内在的 所有自扩张支架在弹性，长度， 直径、纵向柔韧性、环向强度、补片轮廓和输送 系统，影响其性能。 尽管TIPS迄今为止在临床上取得了成功，但仍存在一些重大挑战。 TIPS的早期故障可能是由于以下原因导致的气道闭合所致 氧化铝内生物渗漏！血栓形成、支架扩张不完全或支架 迁移更常见的情况是，TIPS通畅性逐渐受损， 由于组织向内生长，放置后数月。这些和其它限制 必须解决当前TIPS实践的问题，以确保持久的通畅性， TIPS的有效率。这是第一阶段项目的具体目标， 为了解决这些限制中的一些， 镍钛合金支架与粘附聚合物腔内层结合。伯克利 应用科学与工程公司（基础）开发了一个独特的专业知识， 将镍钛诺用于各种工业和医疗应用。的 Slepian博士，是最初的发明者和开发者， 聚合物腔内铺筑。在第一阶段，将结合各种优势， 利用，包括数学模拟基地和聚合物的专业知识 Slepian实验室。将制造原型支架样品， 将进行动物研究，以证明TIPS的现有局限性 程序可以改进。 拟定商业应用： 不可用