HIV PREVENTION TRIAL UNIT (HPTU)

描述(改编自申请人的摘要)：本申请提出 成立一个由四个机构组成的联合体--东部预防审判股 (EPTU)由耶鲁大学公共卫生学院(康涅狄格州纽黑文)、 纽约州立大学/下州医学中心(SUNY-DMC)(布鲁克林， 纽约)，艾滋病生物医学中心/圣彼得堡国立大学(圣彼得堡州立大学)(圣彼得堡)。 和艾滋病干预研究中心(CAIR)在 威斯康星医学院(密尔沃基，威斯康星州)。调查人员 建议加入HPTN协议，适合居住在 康涅狄格州、布鲁克林和俄罗斯圣彼得堡。MCW将做出贡献 EPTU在社区行为干预研究方面的专业知识， 尤其是在俄罗斯。所有四个机构都有重叠的地理位置 和美国东部艾滋病毒预防方面的研究兴趣(正在进行的联合 研究)和东欧(艾滋病国际培训和研究方案 在俄罗斯[耶鲁/MCW/SPSU]和东欧[SUNY-DMC])。EPTU可以 通过以下方式为HPTN作出贡献：(1)确定有效的预防战略； 以及(2)通过该股的大型国际组织为其评价提供便利 人口容量(康涅狄格州和布鲁克林的人口基数为600万 圣彼得堡有600万人)。这一人口基础中的很大一部分人 高艾滋病毒发病率是由政治、经济、社会和 人口不稳定。 该应用程序将四个显著优势归因于建议的 财团。首先，它可以为艾滋病毒携带者提供接触 流行病仍处于早期阶段(圣彼得堡)，其中 疫情已经成熟(布鲁克林和康涅狄格州)。其次，它感染了艾滋病毒 招聘所需的预防研究管理技能和现场专业知识 并在预防干预试验中保留这些人群。第三，它有 国家和国际理论和实践科学专长 协助HPTN执行其广泛而复杂的任务。第四, EPTU有能力扩大以增加高风险或 参加更大规模的预防干预研究的感染者。 耶鲁/MCW/SPSU圣彼得堡AITRPP已经建立了与 俄罗斯各地有关的批评性非政府组织(NGO) 关于爱滋病。纽约州立大学DMC的AITRP也有类似的联系，可以促进 扩展到波兰的地点。刚果金沙萨的SIDA项目是一个 可纳入EPTU的其他可能的合作者应 HPTN补充资金将在晚些时候提供。

DESCRIPTION (adapted from applicant's abstract): This application proposes formation of a four-institution consortium, the Eastern Prevention Trials Unit (EPTU) consisting of Yale University School of Public Health (New Haven, CT), State University of New York/Downstate Medical Center (SUNY-DMC) (Brooklyn, NY), the Biomedical Center on AIDS/St. Petersburg State University (SPSU) (St. Petersburg, Russia) and the Center for AIDS Intervention Research (CAIR) at the Medical College of Wisconsin (MCW) (Milwaukee, WI). The investigators propose to enroll into HPTN protocols suitable individuals residing in Connecticut, Brooklyn and St. Petersburg, Russia. MCW will contribute expertise in community-based behavioral intervention studies to the EPTU, particularly in Russia. All four institutions have overlapping geographical and research interests in HIV prevention in the eastern US (ongoing joint studies) and Eastern Europe (AIDS International Training and Research Programs in Russia [Yale/MCW/SPSU] and Eastern Europe [SUNY-DMC]). The EPTU could contribute to the HPTN by: (1) identifying effective prevention strategies; and (2) facilitating their evaluation through the Unit's large international population capacity (population base of 6 million in Connecticut and Brooklyn and 6 million in St. Petersburg). Large segments of this population base have high HIV incidence rates driven by political, economic, social, and demographic instability. The application attributes four significant strengths to the proposed consortium. First, it could provide access to populations in which the HIV epidemic is still in its early phases (St. Petersburg) and in which the epidemic has matured (Brooklyn and Connecticut). Second, it has HIV prevention research management skills and on-site expertise needed to recruit and retain these populations in prevention intervention trials. Third, it has the national and international theoretical and practical scientific expertise to assist the HPTN in carrying out its extensive and complex mandate. Fourth, the EPTU has the capacity to expand to increase the number of high-risk or infected individuals for enrollment in larger prevention intervention studies. The Yale/MCW/SPSU St. Petersburg AITRPP has established linkage points with critical non-governmental organizations (NGOs) throughout Russia concerned about AIDS. The AITRP at SUNY-DMC has similar connections that can foster expansion to sites in Poland. Project SIDA in Kinshasa, Congo, is an additional possible collaborator that could be brought into the EPTU should HPTN supplemental funds become available at a later date.