COGNITIVE EVENT-RELATED POTENTIALS AND BRAIN MATURATION

大脑额叶的成熟可能起着重要的作用 信息处理能力的发展。EEG记录 和事件相关电位（ERP）允许检查区域 大脑在特定信息处理过程中的活动 任务本研究计划的目标是：1）建立 通过青春期发育的电生理学标志物;以及2） 将电生理数据与认知性能变化相关联， 发生在青春期。这个过程将使我们能够将大脑区域 从电生理数据到行为数据 年龄的变化。本研究提出三个假设：1）事件相关电位模式 反映特定认知功能的大脑活动 不同年龄的参与者; 2）与后部区域相关的ERP 在比ERP更年轻的时候， 与大脑的额叶区域相关;以及3）ERP数据将 与行为任务的表现相关。这些假设将是 测试通过检查ERP组件记录，而儿童和青少年 成年人执行特定的信息处理任务。 这个指导研究科学家奖的教育目标是： 1)PI将扩大研究技能和扩展研究网络。席德博士 Segalowitz将在实验室担任这一经验的导师。的 PI将参加加强实验室经验的课程。（二） 推进PI的研究意愿，并开发新的研究项目， 临床康复干预。这将通过以下方式实现： 完成研究计划和启动试点研究 研究残疾儿童的ERP模式。3)促进 传播研究成果和实验室管理的技能。 PI将为同行评审的期刊准备报告 这些研究的结果，并监督研究生在相关的 研究项目。

The maturation of the frontal lobe of the brain may play an important role in the development of information processing abilities. Recordings of EEG and event-related potentials (ERPs) permit the examination of regional brain activity during the performance of specific information processing tasks. The goals of this research plan are: 1) to establish electrophysiological markers of development through adolescence; and 2) to relate the electrophysiological data to cognitive performance changes that occur in adolescence. This process will allow us to relate regional brain development as reflected in electrophysiological data to behavioral changes across ages. Three hypotheses are to be examined: 1) ERP patterns that are reflective of specific cognitive functioning will vary for participants of different ages; 2) ERPs associated with posterior regions of the brain will manifest adult properties at a younger age than ERPs associated with frontal regions of the brain; and 3) the ERP data will correlate with performance on behavioral tasks. These hypothesis will be tested by examining ERP components recorded while children and young adults perform specific information processing tasks. The educational objectives of this mentored research scientist award are: 1) The PI will expand research skills and extend research network. Dr. Sid Segalowitz will serve as mentor for this experience in the laboratory. The PI will attend courses that reinforce the laboratory experience. 2) Advance research wills of PI and develop new research projects addressing clinical intervention in rehabilitation. This will be accomplished through the completion of the research plan and the initiation of pilot studies that will examine ERP patterns in children with disabilities. 3) Promote skills in the dissemination of research results and laboratory management. The PI will prepare manuscripts for peer reviewed journals reporting the results of these studies and supervise graduate students in related research projects.