NTP-CHEMICALS IN LABORATORY ANIMALS

本合同的目的是进行研究，以评估经口腔和皮肤接触的选定化学品的毒性和致癌潜力。该项目被划分为任务，与测试化学品相关的所有活动被认为是一个任务。基础合同应由第一阶段（启动前活动）或二异丙基碳二亚胺（任务1）、亚甲基蓝（任务2）、溴氯乙酸（任务3）、二溴乙腈（任务4）、二氯乙酸（任务5）和溴二氯乙酸（任务6）组成。在第一阶段，承包商应从事与确定散装化学品纯度和特性、剂量配方/分析方法的验证、在研究开始前必须解决的任何健康和安全问题有关的工作活动，并且仅从事第一阶段中明确包括的其他方面的工作。

The purpose of this contract is to conduct studies to evaluate the toxic and carcinogenic potential of selected chemicals by oral and dermal exposure. This project is divided into Tasks with all activities associated with a test chemical considered a Task. The Base Contract shall consist of Phase 1 (prestart activities) or Diisopropylcarbodiimide (Task 1), Methylene Blue (Task 2), Bromochloroacetic Acid (Task 3), Dibromoacetonitrile (Task 4), Dichloroacetic Acid (Task 5), and Bromodichloroacetic Acid (Task 6). During phase 1, the contractor shall perform those work activities associated with the determination of bulk chemical purity and identity, and validation of dose formulation/analysis methods, any health and safety concerns that must be addressed before study start, and only those other aspects specifically included in Phase 1.